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The Effect of Physical Activity on the Brain

The recruitment status of this study is unknown. The completion date has passed and the status has not been verified in more than two years.
Verified June 2012 by University Hospital Muenster.
Recruitment status was:  Active, not recruiting
Sponsor:
ClinicalTrials.gov Identifier:
NCT01475396
First Posted: November 21, 2011
Last Update Posted: June 19, 2012
The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details.
Collaborator:
German Federal Ministry of Education and Research
Information provided by (Responsible Party):
University Hospital Muenster
November 7, 2011
November 21, 2011
June 19, 2012
March 2006
March 2012   (Final data collection date for primary outcome measure)
  • Change of reaction times in ms in a motor learning task after 6 months of intervention/control condition [ Time Frame: 6 months ]
  • Change of delayed memory scores in #of words in a Verbal learning task after 6 months of intervention/control condition [ Time Frame: 6 months ]
  • Change of performance in ms in a reaction time task after 6 months of intervention/control condition [ Time Frame: 6 months ]
  • Change of relative regional grey matter volumes in % measured by T1-weighted MRI after 6 months of intervention/control condition [ Time Frame: 6 months ]
Same as current
Complete list of historical versions of study NCT01475396 on ClinicalTrials.gov Archive Site
  • Change of physical measurements (ECG)/fitness assessments (lactate) after 6 months of intervention/control condition [ Time Frame: 6 months ]
  • Change of BDNF blood serum levels in ng/dl after 6 months of intervention/control condition [ Time Frame: 6 months ]
Same as current
Not Provided
Not Provided
 
The Effect of Physical Activity on the Brain
Clinical Study on the Effect of Physical Activity on Cognition and Memory in the Elderly
Physical activity is thought to increase overall body functions and to decrease cardiovascular and stroke risk factors. Now the question arose, wether enhanced exercise could also exert positive influence on cognition in the aging brain. Therefore, 50 to 80 years old healthy subjects take part in a prospective study with regular sports activity during 6 months. Cognitive functions are detected with sensitive neuropsychological outcome measures, further investigations include MRT of the head, lactat- and other physical measures as well as detailed serum profiles. As a hypothesis, enhanced physical activity is suggested to predict better cognitive performance.
Not Provided
Interventional
Phase 3
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: Triple (Participant, Investigator, Outcomes Assessor)
Primary Purpose: Prevention
  • Aerobic Exercise
  • Anaerobic Exercise
  • Unchanged Condition
Behavioral: exercise
  • Experimental: Aerobic Exercise
    Intervention: Behavioral: exercise
  • Experimental: Anaerobic Exercise
    Intervention: Behavioral: exercise
  • No Intervention: Unchanged condition
Not Provided

*   Includes publications given by the data provider as well as publications identified by ClinicalTrials.gov Identifier (NCT Number) in Medline.
 
Unknown status
120
December 2012
March 2012   (Final data collection date for primary outcome measure)

Inclusion Criteria:

  • 50-80 years old
  • healthy
  • lesser activity

Exclusion Criteria:

  • regular physical activity
  • diabetes
  • stroke
  • heavy smoking, drinking,
  • BMI < 20
  • MMSE < 25
Sexes Eligible for Study: All
50 Years to 80 Years   (Adult, Senior)
Yes
Contact information is only displayed when the study is recruiting subjects
Germany
 
 
NCT01475396
Exercise_Neuromod
No
Not Provided
Not Provided
University Hospital Muenster
University Hospital Muenster
German Federal Ministry of Education and Research
Principal Investigator: Agnes Flooel, MD University Hospital of Muenster
Study Director: Stefan Knecht, MD University Hospital of Muenster
University Hospital Muenster
June 2012

ICMJE     Data element required by the International Committee of Medical Journal Editors and the World Health Organization ICTRP