ClinicalTrials.gov
ClinicalTrials.gov Menu

MRA/fMRI Study of Spontaneous Migraine

The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details.
ClinicalTrials.gov Identifier: NCT01471314
Recruitment Status : Unknown
Verified August 2012 by Faisal Mohammad Amin, Glostrup University Hospital, Copenhagen.
Recruitment status was:  Recruiting
First Posted : November 15, 2011
Last Update Posted : August 29, 2012
Sponsor:
Collaborator:
Leiden University Medical Center
Information provided by (Responsible Party):
Faisal Mohammad Amin, Glostrup University Hospital, Copenhagen

November 10, 2011
November 15, 2011
August 29, 2012
Not Provided
Not Provided
Not Provided
Not Provided
Complete list of historical versions of study NCT01471314 on ClinicalTrials.gov Archive Site
Not Provided
Not Provided
Not Provided
Not Provided
 
MRA/fMRI Study of Spontaneous Migraine
Functional MRI and MR Angiography Used in Spontaneous Migraine

The purpose of this study is to examine migraineurs during spontaneous migraine attacks without aura, using high resolution magnetic resonance imaging (MRI), to study following:

  • Changes in resting state blood-oxygenation-level-dependent-signal (BOLD-signal) using functional MRI (fMRI).
  • Changes in circumferences of intra- and extracranial arteries using MR-angiography (MRA).
  • Changes in regional and global cerebral blood flow (CBF) using the arterial spin labeling (ASL) method.

Moreover to perform diffusion tensor imaging (DTI) scans during spontaneous migraine attacks.

The migraine specific drug sumatriptan will be given to relieve pain and the effect will be registered using MRA and fMRI if possible.

Not Provided
Observational
Observational Model: Case-Only
Time Perspective: Cross-Sectional
Not Provided
Not Provided
Probability Sample
Migraine without aura
Headache Versus Non-headache Day
Behavioral: Headache day versus non-headache day
Spontaneous migraine
Intervention: Behavioral: Headache day versus non-headache day
Amin FM, Asghar MS, Hougaard A, Hansen AE, Larsen VA, de Koning PJ, Larsson HB, Olesen J, Ashina M. Magnetic resonance angiography of intracranial and extracranial arteries in patients with spontaneous migraine without aura: a cross-sectional study. Lancet Neurol. 2013 May;12(5):454-61. doi: 10.1016/S1474-4422(13)70067-X. Epub 2013 Apr 9.

*   Includes publications given by the data provider as well as publications identified by ClinicalTrials.gov Identifier (NCT Number) in Medline.
 
Unknown status
Not Provided
Not Provided
Not Provided
Not Provided

Inclusion Criteria:

  • Migraine without aura according to IHS criteria.

Exclusion Criteria:

  • Other primary headaches.
  • Tension-type headache more than 5 days/month.
  • Use of anti-pain medication before the scanning on the examination day.
  • Pregnant or nursing women.
  • Contraindication for MR scan.
  • Anamnestic or clinical signs of cardiovascular or cerebrovascular disease, unregulated psychiatric disease or drug misuse.
  • Other clinical conditions assessed by the examining doctor.
Sexes Eligible for Study: All
18 Years to 60 Years   (Adult)
No
Contact information is only displayed when the study is recruiting subjects
Denmark
 
 
NCT01471314
H-C-2008-089
Yes
Not Provided
Not Provided
Faisal Mohammad Amin, Glostrup University Hospital, Copenhagen
Glostrup University Hospital, Copenhagen
Leiden University Medical Center
Not Provided
Glostrup University Hospital, Copenhagen
August 2012