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Diet Oil Induced Stimulation of GLP-1

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ClinicalTrials.gov Identifier: NCT01453842
Recruitment Status : Completed
First Posted : October 18, 2011
Last Update Posted : December 2, 2014
Sponsor:
Information provided by (Responsible Party):
Katrine Bagge Hansen, University of Copenhagen

October 13, 2011
October 18, 2011
December 2, 2014
March 2011
December 2011   (Final data collection date for primary outcome measure)
Plasma GLP-1 [ Time Frame: 3 hours ]
Glp-1 response is measured during and three hours after ingestion of the different mealtest
Same as current
Complete list of historical versions of study NCT01453842 on ClinicalTrials.gov Archive Site
  • Plasma insulin [ Time Frame: 3 hours ]
    Plasma insulin is measured during and 3 hours after mealtest
  • Plasma glucose [ Time Frame: 3 hours ]
    Plasma glucose is measured during and 3 hours after meal test
  • Plasma GIP [ Time Frame: 3 hours ]
    Plasma GIP is measured during and 3 hours after meal test
  • Plasma glucagon [ Time Frame: 3 hours ]
    Plasma glucagon is measured during and 3 hours after meal test
  • Plasma PYY [ Time Frame: 3 hours ]
    Plasma PYY is measured during and 3 hours after meal test
  • Plasma paracetamol [ Time Frame: 3 hours ]
    Plasma paracetamol is measured during and 3 hours after meal test
Same as current
Not Provided
Not Provided
 
Diet Oil Induced Stimulation of GLP-1
Diet Oil Induced Stimulation of GLP-1
Activation of G protein-coupled receptor GPR119 stimulates glucagon-like peptide-1 (GLP-1)release from the intestinal L-cells. Previously, administration of 2-oleyl-glycerol (2-OG) to humans significantly increased plasma GLP-1. In the present study we want to test the effect in patients with type 2 diabetes. The hypothesis is that we will expect to find a significant increased plasma GLP-1 following a meal containing of 2-OG when compared to meals containing of olive oil or carbohydrates alone.
Activation of G protein-coupled receptor GPR119 stimulates glucagon-like peptide-1 (GLP-1)release from the intestinal L-cells. Previously, administration of 2-oleyl-glycerol (2-OG) to humans significantly increased plasma GLP-1. In the present study we want to test the effect in patients with type 2 diabetes. The hypothesis is that we will expect to find a significant increased plasma GLP-1 following a meal containing of 2-OG when compared to meals containing of olive oil or carbohydrates alone. The aim of the study is to elucidate the effect of 2-OG, 'diet oil' on GLP-1 secretion in patients with type 2 diabetes and to explain the mechanism behind the known stimulation of GLP-1 release by dietary fat.
Interventional
Early Phase 1
Allocation: Randomized
Intervention Model: Crossover Assignment
Masking: Single (Participant)
Primary Purpose: Basic Science
Type 2 Diabetes Mellitus
  • Dietary Supplement: Diet oil
    Carrot and diet oil (containing 2-OG) and 1½ g of paracetamol
  • Dietary Supplement: Olive oil
    Carrot and olive oil and 1½ g of paracetamol
  • Dietary Supplement: Carrot
    Carrot and 1½ g of paracetamol
  • Experimental: Diet oil
    Intervention: Dietary Supplement: Diet oil
  • Active Comparator: Olive oil
    Intervention: Dietary Supplement: Olive oil
  • Placebo Comparator: Carrot
    Intervention: Dietary Supplement: Carrot
Not Provided

*   Includes publications given by the data provider as well as publications identified by ClinicalTrials.gov Identifier (NCT Number) in Medline.
 
Completed
12
Same as current
March 2012
December 2011   (Final data collection date for primary outcome measure)

Inclusion Criteria:

  • Patients with type 2 diabetes mellitus according to the WHO criteria
  • caucasians
  • age above 18 years
  • BMI 20-30

Exclusion Criteria:

  • kidney disease
  • liver disease
  • retinopathy
  • anaemia
  • use of insulin
  • use of GLP-1 analogues
  • use of DPP-4 inhibitors
Sexes Eligible for Study: All
18 Years to 65 Years   (Adult, Older Adult)
No
Contact information is only displayed when the study is recruiting subjects
Denmark
 
 
NCT01453842
Diet oil
No
Not Provided
Not Provided
Katrine Bagge Hansen, University of Copenhagen
University of Copenhagen
Not Provided
Study Chair: Katrine B Hansen, MD University of openhagen
Study Chair: Jens J Holst, Professor University of Copenhagen
Study Chair: Harald S Hansen, Professor University of Copenhagen
University of Copenhagen
December 2014

ICMJE     Data element required by the International Committee of Medical Journal Editors and the World Health Organization ICTRP