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Lymphocytic Herpesviruses and Cerebrospinal Fluid Polymerase Chain Reaction (PCR)

The recruitment status of this study is unknown. The completion date has passed and the status has not been verified in more than two years.
Verified September 2011 by Laura Kupila, PaijatHame Central Hospital.
Recruitment status was:  Not yet recruiting
Sponsor:
ClinicalTrials.gov Identifier:
NCT01438879
First Posted: September 22, 2011
Last Update Posted: September 22, 2011
The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details.
Collaborator:
University of Turku
Information provided by (Responsible Party):
Laura Kupila, PaijatHame Central Hospital
September 20, 2011
September 22, 2011
September 22, 2011
October 2011
October 2013   (Final data collection date for primary outcome measure)
Not Provided
Not Provided
No Changes Posted
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Lymphocytic Herpesviruses and Cerebrospinal Fluid Polymerase Chain Reaction (PCR)
Molecular Methods in the Etiological Diagnostics of Acute Central Nervous System Infections: Lymphocytic Herpesviruses and PCR

Enterovirus and herpes simplex viruses 1 and 2 are the main causative agents of central nervous system infections.

Instead, the role of lymphocytic herpesviruses in the etiology of central nervous system (CNS) infections is not clear, even if there is the positive cerebrospinal fluid (CSF) polymerase chain reaction (PCR)-result for the virus.

The aim of this study is to evaluate the presence of DNA from lymphocytic herpesviruses in the CSF obtained from the immunocompetent patients with CSF pleocytosis and from the patients with normal CSF leukocyte count.

Not Provided
Observational
Observational Model: Case Control
Time Perspective: Prospective
Not Provided
Retention:   Samples With DNA
Description:
CSF white cells + CSF supernatant, Blood white cells and serum
Non-Probability Sample
Residents of the district of Paijat-Hame (200 000 inhabitants).
Central Nervous System Infection
Not Provided
  • pleocytosis group
    40 patients with clinical signs of CNS infection and having CSF pleocytosis.
  • non-pleocytosis group
    20 patients not having CNS infection clinically and not having CSF pleocytosis.
Not Provided

*   Includes publications given by the data provider as well as publications identified by ClinicalTrials.gov Identifier (NCT Number) in Medline.
 
Unknown status
60
December 2013
October 2013   (Final data collection date for primary outcome measure)

Inclusion Criteria:

  • Immunocompetent patients with clinical symptoms and signs of central nervous system infections and CSF pleocytosis (pleocytosis group)
  • Immunocompetent patients without suspicion of CNS infection and no CSF pleocytosis (non-pleocytosis group)

Exclusion Criteria:

  • Suspicion of CNS-infection, eg. encephalitis, but no CSF leukocytosis (pleocytosis group)
  • Patients without symptoms of CNS infection, but who has CSF pleocytosis of unknown origin (non-pleocytosis group)
Sexes Eligible for Study: All
16 Years to 80 Years   (Child, Adult, Senior)
No
Contact information is only displayed when the study is recruiting subjects
Finland
 
 
NCT01438879
R11077
No
Not Provided
Not Provided
Laura Kupila, PaijatHame Central Hospital
PaijatHame Central Hospital
University of Turku
Principal Investigator: Laura MA Kupila PaijatHame Central Hospital
PaijatHame Central Hospital
September 2011