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Effects of Advanced Glycation Endproducts on Satiety and Inflammation (AGE-1)

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ClinicalTrials.gov Identifier: NCT01434407
Recruitment Status : Completed
First Posted : September 14, 2011
Last Update Posted : September 5, 2012
Sponsor:
Collaborator:
The Ministry of Science, Technology and Innovation, Denmark
Information provided by (Responsible Party):
AAstrup, University of Copenhagen

September 13, 2011
September 14, 2011
September 5, 2012
August 2011
March 2012   (Final data collection date for primary outcome measure)
  • Appetite sensation [ Time Frame: Every 30 min up to 5 hours after test meal ]
    Appetite sensation measured by visual analogue scales
  • Plasma ghrelin [ Time Frame: Continuous measurement up to 5 hours after test meal ]
  • Plasma GLP-1 [ Time Frame: Continuous measurements up to 5 hours after test meal ]
  • Plasma PYY [ Time Frame: Continuous measurements up to 5 hours after test meal ]
  • Plasma insulin [ Time Frame: Continuous measurements up to 5 hours after test meal ]
  • Plasma glucose [ Time Frame: Continuous measurements up to 5 hours after test meal ]
  • Urine AGE [ Time Frame: From 24 hour before to 48 hour after test meal ]
  • Appetite sensation [ Time Frame: Every 30 min up to 5 hours after test meal ]
    Appetite sensation measured by visual analogue scales
  • Plasma ghrelin [ Time Frame: Continuous measurement up to 5 hours after test meal ]
  • Plasma GLP-1 [ Time Frame: Continuous measurements up to 5 hours after test meal ]
  • Plasma PYY [ Time Frame: Continuous measurements up to 5 hours after test meal ]
  • Plasma insulin [ Time Frame: Continuous measurements up to 5 hours after test meal ]
  • Plasma glucose [ Time Frame: Continuous measurements up to 5 hours after test meal ]
  • plasma AGE [ Time Frame: Continuous measurements up to 48 hours after test meal ]
Complete list of historical versions of study NCT01434407 on ClinicalTrials.gov Archive Site
  • Plasma triglycerides [ Time Frame: Continuous measurements up to 5 hours after test meal ]
  • Expression of genes related to AGE [ Time Frame: Continuous measurements up to 24 hours after test meal ]
  • IL-1 beta [ Time Frame: Continuous measurements up to 5 hours after test meal ]
  • IL-6 [ Time Frame: Continuous measurements up to 5 hours after test meal ]
  • TNF-alpha [ Time Frame: Continuous measurements up to 5 hours after test meal ]
  • CRP [ Time Frame: Continuous measurements up to 5 hours after test meal ]
  • VCAM [ Time Frame: Continuous measurements up to 5 hours after test meal ]
  • ICAM [ Time Frame: Continuous measurements up to 5 hours after test meal ]
  • MIF [ Time Frame: Continuous measurements up to 5 hours after test meal ]
  • Plasma AGE [ Time Frame: Continuous measurements up to 48 hours after test meal ]
  • Urine isoprostanes [ Time Frame: From 24 hour before to 24 hours after test meal ]
  • Plasma triglycerides [ Time Frame: Continuous measurements up to 5 hours after test meal ]
  • Expression of genes related to AGE [ Time Frame: Continuous measurements up to 24 hours after test meal ]
  • IL-1 beta [ Time Frame: Continuous measurements up to 5 hours after test meal ]
  • IL-6 [ Time Frame: Continuous measurements up to 5 hours after test meal ]
  • TNF-alpha [ Time Frame: Continuous measurements up to 5 hours after test meal ]
  • CRP [ Time Frame: Continuous measurements up to 5 hours after test meal ]
  • VCAM [ Time Frame: Continuous measurements up to 5 hours after test meal ]
  • ICAM [ Time Frame: Continuous measurements up to 5 hours after test meal ]
  • MIF [ Time Frame: Continuous measurements up to 5 hours after test meal ]
  • Urine AGE [ Time Frame: From 24 before to 48 hours after test meal ]
Not Provided
Not Provided
 
Effects of Advanced Glycation Endproducts on Satiety and Inflammation
Crossover Meal Study Investigating Effects of Advanced Glycation Endproducts on Satiety and Inflammation
The purpose of the meal study is to investigate acute effects on satiety and inflammation of advanced glycation endproducts (AGE) in healthy overweight subjects. The AGE content of the meal is affected by food preparation methods: frying/grilling versus boiling/steaming.
Not Provided
Interventional
Not Applicable
Allocation: Randomized
Intervention Model: Crossover Assignment
Masking: Single (Outcomes Assessor)
Primary Purpose: Prevention
  • Obesity
  • Type 2 Diabetes
  • Insulin Resistance
  • Cardiovascular Disease
Other: Dietary meal intervention
Test meals with different AGE content made by different cooking methods
  • Experimental: Low AGE meal
    Test meal prepared by boiling/steaming the food
    Intervention: Other: Dietary meal intervention
  • Experimental: High AGE meal
    Test meal prepared by frying/grilling the food
    Intervention: Other: Dietary meal intervention
Poulsen MW, Bak MJ, Andersen JM, Monošík R, Giraudi-Futin AC, Holst JJ, Nielsen J, Lauritzen L, Larsen LH, Bügel S, Dragsted LO. Effect of dietary advanced glycation end products on postprandial appetite, inflammation, and endothelial activation in healthy overweight individuals. Eur J Nutr. 2014;53(2):661-72. doi: 10.1007/s00394-013-0574-y. Epub 2013 Aug 9.

*   Includes publications given by the data provider as well as publications identified by ClinicalTrials.gov Identifier (NCT Number) in Medline.
 
Completed
19
12
March 2012
March 2012   (Final data collection date for primary outcome measure)

Inclusion Criteria:

  • Healthy males and females between 20 and 50 years old
  • BMI 25-40
  • Waist circumference above 88 cm for women and above 102 cm for men

Exclusion Criteria:

  • Exercise training above 8 hour/week
  • Smoking
  • Pregnant or breast-feeding women
  • Post-menstrual women
  • Regular use of medicine (except contraceptive pills)
  • Previous gastric bypass surgery
  • Donation of blood within the last 3 months
  • Involvement in other clinical trials
  • Allergic to paraaminobenzoic acid
Sexes Eligible for Study: All
20 Years to 50 Years   (Adult)
Yes
Contact information is only displayed when the study is recruiting subjects
Denmark
 
 
NCT01434407
M200
Yes
Not Provided
Not Provided
AAstrup, University of Copenhagen
University of Copenhagen
The Ministry of Science, Technology and Innovation, Denmark
Principal Investigator: Susanne G Bügel Department of Human Nutrition, University of Copenhagen
University of Copenhagen
September 2012

ICMJE     Data element required by the International Committee of Medical Journal Editors and the World Health Organization ICTRP