Studying Genes in Samples From Younger Patients With Desmoplastic Small Round Cell Tumor Registered on COG-D9902 or COG-ABTR01B1

This study is ongoing, but not recruiting participants.
Sponsor:
Collaborator:
Information provided by (Responsible Party):
Children's Oncology Group
ClinicalTrials.gov Identifier:
NCT01430637
First received: September 7, 2011
Last updated: May 8, 2015
Last verified: May 2015

September 7, 2011
May 8, 2015
September 2011
January 2100   (final data collection date for primary outcome measure)
  • Identification of novel mutations, single nucleotide polymorphisms, and copy number changes associated with DSRCT [ Designated as safety issue: No ]
  • Identification of genomic regions involved in pathogenesis of DSRCT [ Designated as safety issue: No ]
Same as current
Complete list of historical versions of study NCT01430637 on ClinicalTrials.gov Archive Site
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Studying Genes in Samples From Younger Patients With Desmoplastic Small Round Cell Tumor Registered on COG-D9902 or COG-ABTR01B1
Comprehensive Genome Sequencing of Desmoplastic Small Round Cell Tumors

RATIONALE: Studying samples of blood and tumor tissue from patients with cancer in the laboratory may help doctors learn more about changes that occur in DNA and identify biomarkers related to cancer.

PURPOSE: This research study is studying genes in samples from younger patients with desmoplastic small round cell tumor registered on COG-D9902 or COG-ABTR01B1.

OBJECTIVES:

  • To perform whole-exome sequencing on desmoplastic small round cell tumor (DSRCT) samples and their available matched normal samples to identify novel mutations, single nucleotide polymorphisms, or copy number changes associated with these tumors.
  • To identify regions of interest that may be involved in the pathogenesis (including the region of EWSR1-WT1 translocation) from the whole-exome sequencing and perform detailed resequencing and transcriptone sequencing to further define the molecular aberrations at the RNA level.

OUTLINE: This is a multicenter study.

Archived tumor tissue samples are analyzed for DNA sequencing, effects of RNA on gene expression levels, novel RNA isoforms, splice variants, and translocations.

Observational
Observational Model: Case Control
Time Perspective: Retrospective
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Non-Probability Sample

Patients registered on COG-D9902 or COG-ABTR01B1.

Sarcoma
  • Genetic: DNA analysis
  • Genetic: RNA analysis
  • Genetic: gene expression analysis
  • Genetic: mutation analysis
  • Genetic: nucleic acid sequencing
  • Genetic: polymerase chain reaction
  • Other: laboratory biomarker analysis
  • Other: pharmacogenomic studies
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*   Includes publications given by the data provider as well as publications identified by ClinicalTrials.gov Identifier (NCT Number) in Medline.
 
Active, not recruiting
20
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January 2100   (final data collection date for primary outcome measure)

DISEASE CHARACTERISTICS:

  • Tumor and blood samples from patients registered on COG-D9902 or COG-ABTR01B1 obtained from the Cooperative Human Tissue Network (CHTN) and the Children's Oncology Group (COG) tumor banks
  • Matched normal samples

PATIENT CHARACTERISTICS:

  • Not specified

PRIOR CONCURRENT THERAPY:

  • Not specified
Both
up to 50 Years
No
Contact information is only displayed when the study is recruiting subjects
Not Provided
 
NCT01430637
ARST11B5, COG-ARST11B5, ARST11B5, NCI-2011-03455
No
Children's Oncology Group
Children's Oncology Group
National Cancer Institute (NCI)
Principal Investigator: Pooja Hingorani, MD Phoenix Children's Hospital
Children's Oncology Group
May 2015

ICMJE     Data element required by the International Committee of Medical Journal Editors and the World Health Organization ICTRP