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Alzheimer's Disease Core Center (ADCC)

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ClinicalTrials.gov Identifier: NCT01421420
Recruitment Status : Recruiting
First Posted : August 22, 2011
Last Update Posted : June 12, 2015
Sponsor:
Collaborators:
Banner Health
Barrow Neurological Foundation
Mayo Clinic
National Institute on Aging (NIA)
National Institutes of Health (NIH)
Information provided by (Responsible Party):
University of Arizona

July 25, 2011
August 22, 2011
June 12, 2015
July 2001
December 2024   (Final data collection date for primary outcome measure)
Neuropsychological Test Scores [ Time Frame: Up to 20 years ]
Cognitive function will be evaluated on a yearly basis using a battery of neuropsychological tests, which will then be scored and normed according to established guidelines.
Same as current
Complete list of historical versions of study NCT01421420 on ClinicalTrials.gov Archive Site
  • Neurological Exam [ Time Frame: Up to 20 Years ]
    A thorough neurological exam will be performed once per year to evaluate neurological function.
  • Brain Tissue [ Time Frame: From date of entry until date of death assessed up to 20 years ]
    A brain autopsy will be performed upon the participant's death to establish histological diagnosis.
Same as current
Not Provided
Not Provided
 
Alzheimer's Disease Core Center
Arizona Alzheimer's Disease Core Center

The main objective of this research project is to provide a comprehensive clinical database of patients with Alzheimer's disease (AD) and other forms of dementia, individuals with mild cognitive impairment (MCI), and age-matched normal controls. The study will also attempt to identify cognitively normal individuals at genetically defined risk for Alzheimer's disease through genetic screening.

All participants are seen annually. Autopsies to establish diagnoses in patients with dementia, patients with mild MCI, and cognitively normal elderly control subjects will also be conducted.

All participants are seen annually. In addition to a detailed neurological examination, participants will receive a standardized battery of neuropsychological tests and will undergo genetic testing. The investigators will provide standardized periodic longitudinal assessment of the research participants. Autopsies to establish neurohistopathological diagnoses in clinically well-characterized patients with dementia, patients with mild MCI, and cognitively normal elderly control subjects will also be conducted.
Observational
Observational Model: Cohort
Time Perspective: Prospective
Not Provided
Retention:   Samples With DNA
Description:
blood, saliva, brain tissue
Non-Probability Sample
Individuals with Alzheimer's disease, mild cognitive impairment, other forms of dementia, and normal elderly individuals.
  • Alzheimer's Disease
  • Mild Cognitive Impairment
  • Age-Related Memory Disorders
Not Provided
  • Alzheimer's Disease
  • Mild Cognitive Impairment
  • Other forms of Dementia, not AD
  • Normal Elderly Individuals
Not Provided

*   Includes publications given by the data provider as well as publications identified by ClinicalTrials.gov Identifier (NCT Number) in Medline.
 
Recruiting
900
Same as current
July 2025
December 2024   (Final data collection date for primary outcome measure)

Inclusion Criteria:

For patients with MCI, or dementia, the presence of cognitive deficits including memory, language, and executive function.

Exclusion Criteria:

Presence of non-neurological medical conditions interfering with cognition.

Sexes Eligible for Study: All
50 Years and older   (Adult, Older Adult)
Yes
United States
 
 
NCT01421420
P30AG019610( U.S. NIH Grant/Contract )
P30AG019610 ( U.S. NIH Grant/Contract )
No
Not Provided
Not Provided
University of Arizona
University of Arizona
  • Banner Health
  • Barrow Neurological Foundation
  • Mayo Clinic
  • National Institute on Aging (NIA)
  • National Institutes of Health (NIH)
Principal Investigator: Steven Z Rapcsak, M.D. University of Arizona
University of Arizona
January 2015