Role of Adiponectin and Endothelial Progenitor Cells in Reperfusion Injury in Patients With Acute Myocardial Infarction (R²ACE)

The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details. Identifier: NCT01414452
Recruitment Status : Completed
First Posted : August 11, 2011
Last Update Posted : July 21, 2015
Information provided by (Responsible Party):
M Claeys, Universiteit Antwerpen

August 10, 2011
August 11, 2011
July 21, 2015
April 2011
December 2012   (Final data collection date for primary outcome measure)
occurrence of reperfusion injury after succesfull primary PCI [ Time Frame: within 90 min after PCI ]
Serial ECG measurements (before and after PCI to assess extent of ST segment resolution as marker of reperfusion injury
Same as current
Complete list of historical versions of study NCT01414452 on Archive Site
Major cardiovascular event rate [ Time Frame: at 1 year ]
combined endpoint of hospitalisation (or extension of hospitalisation) for heart failure and cardiac death in a period of one year
Same as current
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Role of Adiponectin and Endothelial Progenitor Cells in Reperfusion Injury in Patients With Acute Myocardial Infarction
Reperfusion Injury and Cardiac Remodelling After Myocardial Infarction in Relation to Adiponectin Level, Circulating Endothelial Progenitor Cells and Endothelial Microparticles
There is experimental evidence that low levels of adiponectin are associated with more reperfusion injury. In addition experimental studies have demonstrated that endothelial progenitor cells may have a favorable effect on remodeling, mainly through stimulation of neo-revascularisation. Clinical data on these issues are lacking. This clinical project studies the role of adiponectin, endothelial progenitor cells and endothelial microparticles in the ischaemia-reperfusion process and the compensatory ventricular remodelling in a population of 250 infarction patients treated with primary PCI. If the role of these factors could be confirmed in this clinical setting, those factors might represent a new target for therapeutic interventions in AMI patients.
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Observational Model: Cohort
Time Perspective: Prospective
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Retention:   Samples Without DNA
blood samples
Probability Sample
ST elevetion myocardial infarction patients
  • Myocardial Infarction
  • Reperfusion Injury
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STEMI patients
Patients with ST elevation myocardial infarction,lasting <12 hour, who were succesfully treated with primary PCI
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*   Includes publications given by the data provider as well as publications identified by Identifier (NCT Number) in Medline.
Same as current
December 2013
December 2012   (Final data collection date for primary outcome measure)

Inclusion Criteria:

  • STEMI treated with primary PCI

Exclusion Criteria:

  • ischemia time >12h
  • use of immunosuppressive therapy
  • unsuccessful recanalisation
  • not-interpretable ST-T segment
Sexes Eligible for Study: All
Child, Adult, Senior
Contact information is only displayed when the study is recruiting subjects
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M Claeys, Universiteit Antwerpen
Universiteit Antwerpen
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Principal Investigator: Marc Claeys, MD PHD University Hospital, Antwerp
Universiteit Antwerpen
July 2015