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Disturbance of Water and Sodium Metabolism After Surgery of Sellar Lesions, and Correspond Clinical Strategy

The recruitment status of this study is unknown. The completion date has passed and the status has not been verified in more than two years.
Verified April 2011 by Southern Medical University, China.
Recruitment status was:  Recruiting
Sponsor:
ClinicalTrials.gov Identifier:
NCT01406041
First Posted: July 29, 2011
Last Update Posted: July 29, 2011
The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details.
Information provided by:
Southern Medical University, China
July 28, 2011
July 29, 2011
July 29, 2011
February 2011
January 2013   (Final data collection date for primary outcome measure)
Blood sodium [ Time Frame: 24 hours ]
Normal: 135~155
Same as current
No Changes Posted
Urine sodium [ Time Frame: 24 hours ]
Same as current
Not Provided
Not Provided
 
Disturbance of Water and Sodium Metabolism After Surgery of Sellar Lesions, and Correspond Clinical Strategy
Not Provided
The fluid and electrolyte imbalance (FEI) is pretty common encountered during the clinical process of patients suffered sellar lesions. Moreover, if the patients are undergone the surgery for remove the lesion, FEI happens in all cases without exception. Hypo- and hyper-natremia is the most common electrolyte disorder, which is directly correlated to the patients' outcome. However, in clinical works, different sellar diseases cause variant features of FEI. For example, after the surgery of craniopharyngioma, the hyponatremia and hypernatremia always happen alternatively even without any precursor manifestation. Under this situation, it is quite difficult for fluid supplement. In contrast, the severe FEI will cause poor outcome, even death. So it is necessary to systematically collect and review the clinical data of sellar lesions. Through the analysis of variant FEI patterns of sellar diseases, more precise strategy for clinical fluid replacement will be proposed.
Not Provided
Observational
Observational Model: Case-Only
Time Perspective: Retrospective
Not Provided
Not Provided
Probability Sample
All patients presented in our department suffered with sellar diseases
  • The Patients Suffered With Sellar Diseases
  • The Fluid and Electrolyte Imbalance Happened After Surgery
Biological: Chemical and physical detection
CVP, Urine volume per day, Blood electrolytes, Urine sodium per day, Pituitrin
Diseases
1. Pituitary adenomas; 2. Craniopharyngioma; 3. Sellar germinoma; 4. Sellar tuberalis meningioma; 5. Hypophystis; 6. Sellar glioma; 7. Rathke's cleft cyst; 8. Hypothalamic hamartoma
Intervention: Biological: Chemical and physical detection
Not Provided

*   Includes publications given by the data provider as well as publications identified by ClinicalTrials.gov Identifier (NCT Number) in Medline.
 
Unknown status
350
January 2014
January 2013   (Final data collection date for primary outcome measure)

Inclusion Criteria:

  • 1. Suffered with sellar disease
  • 2. Udergone surgery
  • 3. Have sufficient presurgical and postsurgical clinical data (Including MRI, CT, physical and chemical detection results)

Exclusion Criteria:

  • 1. Without sufficitent clincal data
  • 2. No surgery
Sexes Eligible for Study: All
Child, Adult, Senior
No
Contact information is only displayed when the study is recruiting subjects
China
 
 
NCT01406041
The department of Neurosurgery
Yes
Not Provided
Not Provided
Yuntao Lu/principal investigator, The department of neurosurgery
Southern Medical University, China
Not Provided
Not Provided
Southern Medical University, China
April 2011