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Disturbance of Water and Sodium Metabolism After Surgery of Sellar Lesions, and Correspond Clinical Strategy

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ClinicalTrials.gov Identifier: NCT01406041
Recruitment Status : Unknown
Verified April 2011 by Southern Medical University, China.
Recruitment status was:  Recruiting
First Posted : July 29, 2011
Last Update Posted : July 29, 2011
Information provided by:

July 28, 2011
July 29, 2011
July 29, 2011
February 2011
January 2013   (Final data collection date for primary outcome measure)
Blood sodium [ Time Frame: 24 hours ]
Normal: 135~155
Same as current
No Changes Posted
Urine sodium [ Time Frame: 24 hours ]
Same as current
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Disturbance of Water and Sodium Metabolism After Surgery of Sellar Lesions, and Correspond Clinical Strategy
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The fluid and electrolyte imbalance (FEI) is pretty common encountered during the clinical process of patients suffered sellar lesions. Moreover, if the patients are undergone the surgery for remove the lesion, FEI happens in all cases without exception. Hypo- and hyper-natremia is the most common electrolyte disorder, which is directly correlated to the patients' outcome. However, in clinical works, different sellar diseases cause variant features of FEI. For example, after the surgery of craniopharyngioma, the hyponatremia and hypernatremia always happen alternatively even without any precursor manifestation. Under this situation, it is quite difficult for fluid supplement. In contrast, the severe FEI will cause poor outcome, even death. So it is necessary to systematically collect and review the clinical data of sellar lesions. Through the analysis of variant FEI patterns of sellar diseases, more precise strategy for clinical fluid replacement will be proposed.
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Observational Model: Case-Only
Time Perspective: Retrospective
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Probability Sample
All patients presented in our department suffered with sellar diseases
  • The Patients Suffered With Sellar Diseases
  • The Fluid and Electrolyte Imbalance Happened After Surgery
Biological: Chemical and physical detection
CVP, Urine volume per day, Blood electrolytes, Urine sodium per day, Pituitrin
1. Pituitary adenomas; 2. Craniopharyngioma; 3. Sellar germinoma; 4. Sellar tuberalis meningioma; 5. Hypophystis; 6. Sellar glioma; 7. Rathke's cleft cyst; 8. Hypothalamic hamartoma
Intervention: Biological: Chemical and physical detection
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*   Includes publications given by the data provider as well as publications identified by ClinicalTrials.gov Identifier (NCT Number) in Medline.
Unknown status
January 2014
January 2013   (Final data collection date for primary outcome measure)

Inclusion Criteria:

  • 1. Suffered with sellar disease
  • 2. Udergone surgery
  • 3. Have sufficient presurgical and postsurgical clinical data (Including MRI, CT, physical and chemical detection results)

Exclusion Criteria:

  • 1. Without sufficitent clincal data
  • 2. No surgery
Sexes Eligible for Study: All
Child, Adult, Senior
Contact information is only displayed when the study is recruiting subjects
The department of Neurosurgery
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Yuntao Lu/principal investigator, The department of neurosurgery
Southern Medical University, China
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Southern Medical University, China
April 2011