We are updating the design of this site. Learn more.
Show more
ClinicalTrials.gov
ClinicalTrials.gov Menu

Effects of Exposure to Biomass-burning Air Pollution on Lung Function, Heart Rate Variability and Inflammatory Markers in Sugarcane Workers

This study has been completed.
Sponsor:
ClinicalTrials.gov Identifier:
NCT01371188
First Posted: June 10, 2011
Last Update Posted: June 10, 2011
The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details.
Collaborator:
Conselho Nacional de Desenvolvimento Científico e Tecnológico
Information provided by:
InCor Heart Institute
June 9, 2011
June 10, 2011
June 10, 2011
December 2008
October 2010   (Final data collection date for primary outcome measure)
  • Lung function [ Time Frame: six months ]
    Measurements of lung function in pre harvest and during harvest period
  • Heart rate variability [ Time Frame: six months ]
    To evaluate parameters of heart rate variability in pre harvest and during harvest periods
  • Oxidative stress [ Time Frame: six months ]
    Measurement of blood levels of antioxidant enzymes and malonaldehyde
Same as current
No Changes Posted
Environmental evaluation [ Time Frame: one year ]
Measurement of athmospheric concentration of particulate matter.
Same as current
Not Provided
Not Provided
 
Effects of Exposure to Biomass-burning Air Pollution on Lung Function, Heart Rate Variability and Inflammatory Markers in Sugarcane Workers
Effects of Exposure to Outdoor Air Pollution From Biomass Burning on Lung Function, Heart Rate Variability and Systemic Inflammatory Blood Markers in Sugarcane Workers

Introduction: Non-mechanized sugar cane harvesting preceded by burning, an important and prevalent professional activity of agribusiness segment of the Brazilian economy, exposes workers and people of neighboring towns to high concentrations of pollutants and, therefore, potentially several risks to health hazards.

Objectives: Assessing cardiopulmonary impacts and inflammatory markers in sugarcane workers and volunteers from a nearby town in non-harvest and harvest periods.

Not Provided
Observational
Observational Model: Ecologic or Community
Time Perspective: Prospective
Not Provided
Retention:   Samples With DNA
Description:
Whole blood.
Non-Probability Sample
Population from the city of Mendonça, São Paulo-Brazil, divided into the following groups: sugarcane workers (those who work in sugarcane plantations) and controls (healthy volunteers from the same city)
  • Lung Function
  • Heart Rate Variability
  • Oxidative Stress
  • Systemic Inflammatory Response
Not Provided
  • Controls
    Healthy male volunteers, non-smokers, 20-40yo, living in the city of Mendonça, São Paulo-Brazil.
  • Sugarcane Workers
    Healthy male volunteers, non-smokers, 20-40yo, sugarcane workers, living in the city of Mendonça, São Paulo-Brazil.
Paula Santos U, Zanetta DM, Terra-Filho M, Burdmann EA. Burnt sugarcane harvesting is associated with acute renal dysfunction. Kidney Int. 2015 Apr;87(4):792-9. doi: 10.1038/ki.2014.306. Epub 2014 Sep 17.

*   Includes publications given by the data provider as well as publications identified by ClinicalTrials.gov Identifier (NCT Number) in Medline.
 
Completed
222
February 2011
October 2010   (Final data collection date for primary outcome measure)

Inclusion Criteria:

  • The criteria for inclusion in the study were: age between 20 and 40 years, male gender and being non-smokers (or former-smokers for at least a year and a smoking history of less than 20 pack-years).

Exclusion Criteria:

  • Exclusion criteria were history of cardiovascular or respiratory disease, the use of bronchodilator, non-steroidal anti-inflammatory drugs, anticoagulants or antiplatelet drugs and statins.
Sexes Eligible for Study: Male
20 Years to 40 Years   (Adult)
Yes
Contact information is only displayed when the study is recruiting subjects
Brazil
 
 
NCT01371188
Mendonca
402195/2008 ( Other Identifier: CNPQ )
No
Not Provided
Not Provided
Dr Ubiratan de Paula Santos and Dr. Gustavo Faibischew Prado, InCor
InCor Heart Institute
Conselho Nacional de Desenvolvimento Científico e Tecnológico
Not Provided
InCor Heart Institute
June 2011