We updated the design of this site on September 25th. Learn more.
Show more
ClinicalTrials.gov
ClinicalTrials.gov Menu

Dynamic Myocardial Perfusion Imaging by 320 Multidetector Computed Tomography

This study has been completed.
Sponsor:
ClinicalTrials.gov Identifier:
NCT01368237
First Posted: June 7, 2011
Last Update Posted: October 28, 2014
The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details.
Collaborator:
NHS Lothian
Information provided by (Responsible Party):
University of Edinburgh
June 6, 2011
June 7, 2011
October 28, 2014
May 2006
June 2014   (Final data collection date for primary outcome measure)
Myocardial perfusion defects defined qualitatively by trained observers and quantitatively by computer software [ Time Frame: 1 month ]
The primary outcome measure is to establish whether 320-multidetector computed tomography can identify myocardial perfusion defects as compared to the gold standards of 3Tesla magnetic resonance imaging and fractional flow reserve measured during invasive coronary angiography.
Myocardial perfusion defects defined qualitatively by trained observers and quantitatively by computer software [ Time Frame: 1 month ]
The primary outcome measure is to establish whether 320-multidetector computed tomography can identify myocardial perfusion defects as compared to the gold standards of 3T magnetic resonance imaging and fractional flow reserve measured during invasive coronary angiography.
Complete list of historical versions of study NCT01368237 on ClinicalTrials.gov Archive Site
  • Identification of regional wall motion abnormalities qualitatively by trained observers [ Time Frame: 1 month ]
    Our secondary outcome measures are to assess the performance of 320-multidetector computed tomography in the detection of regional wall motion abnormalities in comparison to those obtained with 3Tesla cardiac magnetic resonance imaging.
  • Identification of infarction qualitatively by trained observers [ Time Frame: 1 month ]
    Our secondary outcome measures are to assess the performance of 320-multidetector computed tomography in the detection of infarction in comparison to those obtained with 3Tesla cardiac magnetic resonance imaging.
  • Identification of regional wall motion abnormalities quantitatively by computer software [ Time Frame: 1 month ]
    Our secondary outcome measures are to assess the performance of 320-multidetector computed tomography in the detection of regional wall motion abnormalities in comparison to those obtained with 3Tesla cardiac magnetic resonance imaging.
  • Identification of infarction qualitatively by computer software [ Time Frame: 1 month ]
    Our secondary outcome measures are to assess the performance of 320-multidetector computed tomography in the detection of infarction in comparison to those obtained with 3Tesla cardiac magnetic resonance imaging.
Identification of regional wall motion abnormalities, fibrosis and infarction qualitatively by trained observers and quantitatively by computer software [ Time Frame: 1 month ]
Our secondary outcome measures are to assess the performance of 320-multidetector computed tomography in the detection of regional wall motion abnormalities, fibrosis and infarction in comparison to those obtained with 3T cardiac magnetic resonance imaging.
Not Provided
Not Provided
 
Dynamic Myocardial Perfusion Imaging by 320 Multidetector Computed Tomography
Dynamic Myocardial Perfusion Imaging by 320 Multidetector Computed Tomography
Recent advances in technology have resulted in the development of scanners that can image the heart blood vessels within 10 to 20 minutes but without the need for admission to hospital or insertion of catheters. Further advances in technology allow the visualisation of both the blood vessels and the supply of blood to the heart muscle. Here we propose to assess the latest and most powerful computed tomography scanner and compare it to magnetic resonance and conventional coronary angiography.
Not Provided
Observational
Observational Model: Case-Only
Time Perspective: Cross-Sectional
Not Provided
Not Provided
Non-Probability Sample
Patients awaiting invasive coronary angiography
Coronary Heart Disease
Radiation: Computed tomography scan
Computed tomography will be performed using a 320 multidetector computed tomography scanner and may include coronary calcium score, coronary angiography and imaging of myocardial perfusion, function and viability.
Patients
Patients awaiting invasive coronary angiography
Intervention: Radiation: Computed tomography scan
Not Provided

*   Includes publications given by the data provider as well as publications identified by ClinicalTrials.gov Identifier (NCT Number) in Medline.
 
Completed
75
Not Provided
June 2014   (Final data collection date for primary outcome measure)

Inclusion Criteria:

  • referred for invasive coronary angiography because of suspected coronary heart disease

Exclusion Criteria:

  • inability or unwillingness to undergo computed tomography or magnetic resonance imaging
  • renal failure (serum creatinine >200 micromol/L or estimated glomerular filtration rate <30 mL/min)
  • hepatic failure
  • allergy to iodinated contrast or gadolinium
  • pregnancy
  • contraindication to adenosine infusion
  • inability to give informed consent
  • inability to perform fractional flow reserve during invasive coronary angiography
Sexes Eligible for Study: All
18 Years and older   (Adult, Senior)
No
Contact information is only displayed when the study is recruiting subjects
United Kingdom
 
 
NCT01368237
210/R/CAR/11
No
Not Provided
Not Provided
University of Edinburgh
University of Edinburgh
NHS Lothian
Principal Investigator: David E Newby University of Edinburgh
University of Edinburgh
October 2014