Biomarker in Tumor Tissue Samples From Patients With Rhabdomyosarcoma

This study is ongoing, but not recruiting participants.
Sponsor:
Collaborator:
Information provided by (Responsible Party):
Children's Oncology Group
ClinicalTrials.gov Identifier:
NCT01365962
First received: June 1, 2011
Last updated: May 8, 2015
Last verified: May 2015

June 1, 2011
May 8, 2015
June 2011
January 2100   (final data collection date for primary outcome measure)
  • Degree of surface IGF-IR expression in RMS tumor tissue [ Designated as safety issue: No ]
  • Feasibility and validity of a mass spectrometry assay for IGF-IR expression on paraffin-embedded tumor tissue [ Designated as safety issue: No ]
Same as current
Complete list of historical versions of study NCT01365962 on ClinicalTrials.gov Archive Site
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Biomarker in Tumor Tissue Samples From Patients With Rhabdomyosarcoma
A Study to Assess and Quantify Surface Insulin-like Growth Factor I Receptor (IGF-IR) in Rhabdomyosarcoma (RMS) Tumor Tissue

RATIONALE: Studying samples of tissue from patients with cancer in the laboratory may help doctors learn more about changes that occur in DNA and identify biomarkers related to cancer.

PURPOSE: This research trial studies biomarkers in tumor tissue samples from patients with rhabdomyosarcoma.

OBJECTIVES:

  • To determine and quantify the degree of surface insulin-like growth factor I receptor (IGF-IR) expression in rhabdomyosarcoma (RMS) tumor tissue.
  • To assess the feasibility and validity of a mass spectrometry assay for IGF-IR expression on paraffin-embedded tumor tissue.

OUTLINE: Paraffin-embedded tumor tissue slides are analyzed for insulin-like growth factor I receptor (IGF-1R) expression by mass spectrometry and correlated with the results obtained by IHC assay.

Observational
Observational Model: Case-Only
Time Perspective: Retrospective
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Non-Probability Sample

Diagnosis of rhabdomyosarcoma.

Sarcoma
  • Genetic: gene expression analysis
  • Other: immunohistochemistry staining method
  • Other: laboratory biomarker analysis
  • Other: mass spectrometry
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*   Includes publications given by the data provider as well as publications identified by ClinicalTrials.gov Identifier (NCT Number) in Medline.
 
Active, not recruiting
60
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January 2100   (final data collection date for primary outcome measure)

DISEASE CHARACTERISTICS:

  • Diagnosis of rhabdomyosarcoma

    • Alveolar or embryonal rhabdomyosarcoma
  • Available samples from the Cooperative Human Tissue Network (CHTN) bank

PATIENT CHARACTERISTICS:

  • Not specified

PRIOR CONCURRENT THERAPY:

  • Not specified
Both
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No
Contact information is only displayed when the study is recruiting subjects
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NCT01365962
ARST11B4, COG-ARST11B4, NCI-2011-02858, ARST11B4
No
Children's Oncology Group
Children's Oncology Group
National Cancer Institute (NCI)
Principal Investigator: Suman Malempati, MD Doernbecher Children's Hospital at Oregon Health and Science University
Children's Oncology Group
May 2015

ICMJE     Data element required by the International Committee of Medical Journal Editors and the World Health Organization ICTRP