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Epicardial Fat, Visceral Fat and Coronary Atherosclerosis

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ClinicalTrials.gov Identifier: NCT01344694
Recruitment Status : Unknown
Verified April 2011 by Ziv Hospital.
Recruitment status was:  Not yet recruiting
First Posted : April 29, 2011
Last Update Posted : May 16, 2011
Sponsor:
Information provided by:
Ziv Hospital

April 27, 2011
April 29, 2011
May 16, 2011
July 2011
February 2012   (Final data collection date for primary outcome measure)
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Complete list of historical versions of study NCT01344694 on ClinicalTrials.gov Archive Site
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Epicardial Fat, Visceral Fat and Coronary Atherosclerosis
Association Between Epicardial Fat, Visceral Fat Accumulation & Cardiovascular Atherosclerosis
Background: Visceral fat is increasingly associated with metabolic syndrome and with fatty liver, a condition carrying a high risk of cardiovascular disease. The independent role of epicardial fat deposition in cardiovascular risk remains unclear.
Background: Visceral fat is increasingly associated with metabolic syndrome and with fatty liver, a condition carrying a high risk of cardiovascular disease. The independent role of epicardial fat deposition in cardiovascular risk remains unclear. Aim: Evaluate the link between epicardial fat, visceral fat, liver fat accumulation and cardiovascular diseases and carotis atherosclerosis in patients with the major cardiovascular risk factors and with or without metabolic syndrome.
Observational
Time Perspective: Retrospective
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Probability Sample
50 patients (age 40-70) with excess of visceral fat (obese), 30 patient with liver fat and 30 sexes, age matched individuals will be recruited.
  • Epicardial Fat
  • Visceral Fat
  • Atherosclerosis
  • Other: patient with liver fat
    30 patient with liver fat
  • Other: pts. with excess of visceral fat
    pts. with excess of visceral fat
  • Other: control
    30 control subjects
  • patient with liver fat
    30 patients with liver fat
    Intervention: Other: patient with liver fat
  • excess of visceral fat
    50 pts. with excess of visceral fat
    Intervention: Other: pts. with excess of visceral fat
  • control
    30 control subjects
    Intervention: Other: control
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*   Includes publications given by the data provider as well as publications identified by ClinicalTrials.gov Identifier (NCT Number) in Medline.
 
Unknown status
110
Same as current
March 2012
February 2012   (Final data collection date for primary outcome measure)

Inclusion Criteria:

  • Patients referred to cardiac CT will be the source of recruitment.
  • patients with excess of visceral fat,
  • 30 patients with liver fat accumulation
  • 30 sex-age-matched individual (controls) will be enrolled. All patients will undergo a complete family history, personal clinical history, physical examination and blood sampling for biochemical analysis.
  • Informed consent will be obtained from each individual.

Exclusion Criteria:

  • subjects with severe morbid obesity (body mass index [BMI] > 40),
  • recent history of acute illness,
  • clinical history of ischemic heart disease and cerebrovascular disease,
  • typical chest pain,
  • previous coronary artery disease,
  • conventional coronary angiography, percutaneous interventions, coronary by pass grafting, renal failure, cancer patients,
  • subjects who take drugs that induces hepatic steatosis ( corticosteroids, estrogens, methotrexate, amiodarone and others)
Sexes Eligible for Study: All
40 Years to 70 Years   (Adult, Older Adult)
Yes
Contact information is only displayed when the study is recruiting subjects
Israel
 
 
NCT01344694
0020-11
Yes
Not Provided
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Dr. Assy Nimer, Ziv Medical center
Ziv Hospital
Not Provided
Principal Investigator: Nimer Assy, md Ziv MC
Ziv Hospital
April 2011