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Relationship Between Gestational Diabetes and Type 2 Diabetes (GDM)

This study is ongoing, but not recruiting participants.
Sponsor:
Information provided by (Responsible Party):
Julie Robitaille, Laval University
ClinicalTrials.gov Identifier:
NCT01340924
First received: March 15, 2011
Last updated: February 13, 2017
Last verified: February 2017

March 15, 2011
February 13, 2017
September 2009
September 2016   (Final data collection date for primary outcome measure)
Glucose tolerance assessed using a 75g-Oral Glucose Tolerance Test (OGTT) in mothers [ Time Frame: 1 year ]
Glucose tolerance assessed using a 75g-Oral Glucose Tolerance Test (OGTT) [ Time Frame: 1 year ]
Complete list of historical versions of study NCT01340924 on ClinicalTrials.gov Archive Site
  • Glycaemic and lipidic profile assessed using a fasting blood sample in children [ Time Frame: 1 year ]
  • overweight/obesity [ Time Frame: 1 year ]
    In mothers and children
  • abdominal obesity [ Time Frame: 1 year ]
    In mothers and children
  • metabolic syndrome [ Time Frame: 1 year ]
    In mothers and children
  • Breastfeeding [ Time Frame: 1 year ]
    In mothers and children
  • Nutrition [ Time Frame: 1 year ]
    In mothers and children
  • Physical activity [ Time Frame: 1 year ]
    In mothers and children
  • overweight/obesity [ Time Frame: 1 year ]
  • abdominal obesity [ Time Frame: 1 year ]
  • inflammatory state [ Time Frame: 1 year ]
  • metabolic syndrome [ Time Frame: 1 year ]
Not Provided
Not Provided
 
Relationship Between Gestational Diabetes and Type 2 Diabetes
Key Determinants of Type 2 Diabetes Prevention Among Women With a History of Gestational Diabetes Mellitus
The overall objective of this research project is to study the impact of preventive practices on the T2D-related risk profile among women with and without prior GDM and their children exposed and unexposed to GDM.
Type 2 diabetes (T2D) is a growing public health problem owing to its prevalence as well as its high morbidity and mortality rates. The identification of high-risk populations is of great importance particularly because the onset of T2D can be prevented or delayed by lifestyle modifications. Among high-risk populations, women with previously diagnosed gestational diabetes mellitus (GDM) are at particularly high risk of developing T2D. The success in reducing the occurrence of T2D among women with previous GDM could be achieved only if appropriate preventive measures are undertaken. According to the American Diabetes Association (ADA) and the Canadian Diabetes Association (CDA), lifestyle modifications aimed at reducing body weight and increasing physical activity are recommended and women are encouraged to be breastfeeding their infants. Certain factors have been suggested as determinants of behavioral practices in women with prior GDM including cognitive and environmental factors. A better understanding of these issues is essential for developing effective preventive strategies and possibly reducing the prevalence of T2D in the population. Moreover, in utero exposure to maternal impaired glucose tolerance or diabetes may increase the risk of developing overweight or diabetes in offspring. Since March 2012 we thus test the presence of childhood metabolic alterations predictive of future T2D in GDM-exposed and unexposed offspring and investigate environmental factors during the postnatal period that are associated with prevention of metabolic alterations.
Observational
Observational Model: Cohort
Time Perspective: Prospective
Not Provided
Retention:   Samples With DNA
Description:
whole blood; serum; white cell.
Non-Probability Sample

In order to avoid selection biases, we plan to recruit 450 women with a history of GDM through administrative data from the Régie de l'assurance maladie du Québec (RAMQ) and children of those mothers.

We plan to recruit 125 women without history of GDM through mail sent to students and employees of local university and children of those mothers.

  • Gestational Diabetes
  • Type 2 Diabetes
Not Provided
Not Provided
Not Provided

*   Includes publications given by the data provider as well as publications identified by ClinicalTrials.gov Identifier (NCT Number) in Medline.
 
Active, not recruiting
450
December 2017
September 2016   (Final data collection date for primary outcome measure)

Inclusion Criteria:

  • Women aged ≥18 years with or without a diagnosis of GDM in the past 3-12 years and their children.

Exclusion Criteria:

  • Pregnant women, women with type 1 diabetes.
Sexes Eligible for Study: Female
18 Years and older   (Adult, Senior)
No
Contact information is only displayed when the study is recruiting subjects
Canada
 
 
NCT01340924
GDM
No
Not Provided
Yes
Not Provided
Julie Robitaille, Laval University
Laval University
Not Provided
Principal Investigator: Julie Robitaille, R.D., Ph.D. Laval University
Laval University
February 2017

ICMJE     Data element required by the International Committee of Medical Journal Editors and the World Health Organization ICTRP