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Evolution of Cellular and Viral Resistance in HIV-infected Patients With Lymphoma (SSAT042)

The recruitment status of this study is unknown. The completion date has passed and the status has not been verified in more than two years.
Verified June 2012 by St Stephens Aids Trust.
Recruitment status was:  Recruiting
Sponsor:
ClinicalTrials.gov Identifier:
NCT01330342
First Posted: April 6, 2011
Last Update Posted: June 11, 2012
The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details.
Information provided by (Responsible Party):
St Stephens Aids Trust
April 1, 2011
April 6, 2011
June 11, 2012
May 2011
May 2014   (Final data collection date for primary outcome measure)
Development of multi-drug resistance (in terms of expression of transmembrane transporters and their transcriptional regulators) in HIV-infected patients with lymphoma. [ Time Frame: 3 years ]
  • Development of multi-drug resistance (in terms of expression of transmembrane transporters and their transcriptional regulators) in HIV-infected patients with lymphoma. [ Time Frame: 3 years ]
  • Development of mutations in the HIV genome that may confer resistance to future treatment for HIV. [ Time Frame: 3 years ]
Complete list of historical versions of study NCT01330342 on ClinicalTrials.gov Archive Site
Development of mutations in the HIV genome that may confer resistance to future treatment for HIV. [ Time Frame: 3 years ]
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Evolution of Cellular and Viral Resistance in HIV-infected Patients With Lymphoma
Evolution of Cellular and Viral Resistance in HIV-infected Patients With Lymphoma
The study's chief objective is to observe the evolution of cellular (in terms of expression of transmembrane transporters and their transcriptional regulators) and viral resistance (in terms of development of mutations in the HIV genome that may confer resistance to future treatment for HIV) in HIV-infected patients with lymphoma.

The study team will take two or three tubes of blood on three occasions during the course of chemotherapy. The total amount of blood required for this research project is 64mL (approximately 4 tablespoons).

This will allow better understanding of the changes that take place in the blood and the HIV virus itself. It is hoped that this will provide new insights that may aid the understanding and treatment of HIV patients with lymphoma.

Observational
Observational Model: Case Control
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Probability Sample
HIV seropositive individuals with and without lymphoma.
  • HIV
  • Lymphoma
Not Provided
  • HIV patients without lymphoma
    HIV-infected subjects on cART without a diagnosis of lymphoma
  • HIV patients with lymphoma
    HIV seropositive individuals with lymphoma
Not Provided

*   Includes publications given by the data provider as well as publications identified by ClinicalTrials.gov Identifier (NCT Number) in Medline.
 
Unknown status
40
May 2014
May 2014   (Final data collection date for primary outcome measure)

Inclusion Criteria:

  • The ability to understand and sign a written informed consent form, prior to participation in any screening procedure and must be willing to comply with all study requirements.
  • Documented HIV-1 infection.
  • Diagnosis of lymphoma (with the exclusion of the five subjects that will be controls).
  • On cART or about to start cART as part of clinical routine care before the initiation of chemotherapy.

Exclusion Criteria:

- Receiving anti-tuberculosis treatment.

Sexes Eligible for Study: All
Child, Adult, Senior
No
Contact information is only displayed when the study is recruiting subjects
United Kingdom
 
 
NCT01330342
SSAT 042
No
Not Provided
Not Provided
St Stephens Aids Trust
St Stephens Aids Trust
Not Provided
Principal Investigator: Marta Boffito, Dr St Stephen's AIDS Trust
St Stephens Aids Trust
June 2012