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Strategies to Optimize Positive End-expiratory Pressure (PEEP) in Patients With Acute Lung Injury (EIT-PEEP)

The recruitment status of this study is unknown. The completion date has passed and the status has not been verified in more than two years.
Verified March 2011 by University Hospital, Bonn.
Recruitment status was:  Recruiting
Sponsor:
ClinicalTrials.gov Identifier:
NCT01326208
First Posted: March 30, 2011
Last Update Posted: March 30, 2011
The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details.
Information provided by:
University Hospital, Bonn
July 15, 2010
March 30, 2011
March 30, 2011
March 2011
December 2012   (Final data collection date for primary outcome measure)
homogeneity of regional ventilation delay [ Time Frame: up to eight hours ]
influence of different PEEP titration strategies on homogeneity of regional ventilation delay measured by electrical impedance tomography
Same as current
No Changes Posted
pulmonary gas exchange, lung mechanics and ventilation/perfusion matching [ Time Frame: up to eight hours ]
influence of different PEEP titration strategies on pulmonary gas exchange, lung mechanics and ventilation/perfusion matching
Same as current
Not Provided
Not Provided
 
Strategies to Optimize Positive End-expiratory Pressure (PEEP) in Patients With Acute Lung Injury
Influence of Different Strategies to Optimize Positive End-expiratory Pressure on Pulmonary Gas Exchange, Perfusion/Ventilation Matching and Homogeneity of Ventilation in Patients With Acute Lung Injury
The purpose of this study in patients suffering from acute lung injury is to determine whether positive end-expiratory pressure (PEEP) setting guided by electrical impedance tomography (EIT) influences pulmonary gas exchange, lung mechanics, ventilation/perfusion matching and homogeneity of regional ventilation when compared to other PEEP setting strategies such as the open lung concept or the ARDSnet protocol.
Not Provided
Interventional
Phase 2
Allocation: Randomized
Intervention Model: Crossover Assignment
Masking: Single (Participant)
Primary Purpose: Treatment
  • Acute Lung Injury
  • Acute Respiratory Distress Syndrome
  • Respiratory Failure
Procedure: PEEP titration
PEEP is set according to the following protocols, respectively, in a randomized order: ARDSnet table, Open Lung strategy, guided by EIT
Other Name: electrical impedance tomography guided setting of PEEP
Experimental: Acute Lung Injury / ARDS
Patient under mechanical suffering from ALI or ARDS
Intervention: Procedure: PEEP titration
Not Provided

*   Includes publications given by the data provider as well as publications identified by ClinicalTrials.gov Identifier (NCT Number) in Medline.
 
Unknown status
40
June 2013
December 2012   (Final data collection date for primary outcome measure)

Inclusion Criteria:

  • acute lung injury, need for optimization of ventilatory settings

Exclusion Criteria:

  • preexisting chronical lung disease, pneumothorax, pace maker, hemodynamical instability, increased intracranial pressure
Sexes Eligible for Study: All
18 Years to 80 Years   (Adult, Senior)
No
Contact information is only displayed when the study is recruiting subjects
Germany
 
 
NCT01326208
EIT-PEEP-2010
No
Not Provided
Not Provided
Prof. Dr. Christian Putensen, University of Bonn, Dep. of Anesthesiology and Intensive Care Medicine
University Hospital, Bonn
Not Provided
Study Chair: Christian Putensen, MD, Prof University of Bonn
Principal Investigator: Thomas Muders, MD University of Bonn
University Hospital, Bonn
March 2011

ICMJE     Data element required by the International Committee of Medical Journal Editors and the World Health Organization ICTRP