Osteogenic Effects in Human Mesenchymal Stem Cells Enhanced by Wnt Signaling

This study has been completed.
Sponsor:
Information provided by (Responsible Party):
China Medical University Hospital
ClinicalTrials.gov Identifier:
NCT01323894
First received: March 24, 2011
Last updated: June 15, 2016
Last verified: June 2016

March 24, 2011
June 15, 2016
August 2011
August 2012   (final data collection date for primary outcome measure)
Osteogenic Effects in Human Mesenchymal Stem Cells Enhanced by Wnt Signaling/Hydroxyapatite Nanoparticles--Comparisons between Non-viral and Viral administration in Tissue Engineered Bone Regeneration [ Time Frame: 2 years ] [ Designated as safety issue: No ]
August 2011-July 2013
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Complete list of historical versions of study NCT01323894 on ClinicalTrials.gov Archive Site
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Osteogenic Effects in Human Mesenchymal Stem Cells Enhanced by Wnt Signaling
Osteogenic Effects in Human Mesenchymal Stem Cells Enhanced by Wnt Signaling/Hydroxyapatite Nanoparticles--Comparisons Between Non-viral and Viral Administration in Tissue Engineered Bone Regeneration

The first year purpose:

The best concentration of canonical Wnt3a will be investigated in promoting the osteoblastogenesis of human mesenchymal stem cells.

Our previous work is investigating the viral (Adv-BMP-2) administration for the development of a model to generate bones for possible use in clinical settings; the non-viral and viral administrations will be compared for best osteogenesis effects.

The first year purpose:

The best concentration of canonical Wnt3a will be investigated in promoting the osteoblastogenesis of human mesenchymal stem cells.

Observational
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Non-Probability Sample
The patients require surgery ner iliac or abdomen areas
Primary Disease
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*   Includes publications given by the data provider as well as publications identified by ClinicalTrials.gov Identifier (NCT Number) in Medline.
 
Completed
3
July 2013
August 2012   (final data collection date for primary outcome measure)

Inclusion Criteria:

  • age above 10 years old
  • The patients require surgery ner iliac or abdomen areas

Exclusion Criteria:

  • age below 10 years old
Both
10 Years to 80 Years   (Child, Adult, Senior)
No
Contact information is only displayed when the study is recruiting subjects
Taiwan
 
NCT01323894
DMR-99-IRB-122
Yes
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China Medical University Hospital
China Medical University Hospital
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Principal Investigator: Sopha Chia-Ning Chang, M.D. Ph.D. China Medical University Hospital
China Medical University Hospital
June 2016

ICMJE     Data element required by the International Committee of Medical Journal Editors and the World Health Organization ICTRP