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The Impact of High Intensity Exercise Upon EPC Number and Function in Young Women

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ClinicalTrials.gov Identifier: NCT01314573
Recruitment Status : Unknown
Verified March 2011 by University of Leeds.
Recruitment status was:  Not yet recruiting
First Posted : March 14, 2011
Last Update Posted : March 14, 2011
Sponsor:
Information provided by:
University of Leeds

March 11, 2011
March 14, 2011
March 14, 2011
March 2011
September 2012   (Final data collection date for primary outcome measure)
Maximal oxygen uptake [ Time Frame: 4 weeks ]
A measure of aerobic capacity determined during an incremental exercise test to volitional fatigue on an exercise ergometer.
Same as current
No Changes Posted
  • Heart rate variability [ Time Frame: 4 weeks ]
  • Endothelial progenitor cell function [ Time Frame: 4 weeks ]
    measures of in vitro cell migratory ability, adhesion and classification of endothelial progenitor cells
  • Flow mediated dialtion [ Time Frame: 4 weeks ]
    Measure of vascular endothelial function determined non-invasively at the brachial artery
  • Arterial stiffness [ Time Frame: 4 weeks ]
    The stiffness of the carotid artery is measured using a combination of ultrasound imaging and non-invasive blood pressure measurements. Lower degrees of stiffness are more favourable.
  • Circulating angiogenic cell numbers [ Time Frame: 4 weeks ]
    These cells are involved in vascular repair and proliferation and may be measured using flow cytometric methods. Specifically cells with CD34 and CD309 antigens are enumerated.
  • Endothelial progenitor cell function [ Time Frame: 4 weeks ]
    Measure of in vitro migratory, adhesion and classification of endothelial progenitor cells.
Same as current
Not Provided
Not Provided
 
The Impact of High Intensity Exercise Upon EPC Number and Function in Young Women
The Impact of High Intensity Exercise Upon EPC Number and Function in Young Women
The purpose of the study is to examine the effects of different exercise intensity training programs upon blood vessel function and circulating blood cells involved in blood vessel repair in young women. The long term effects of exercise may be beneficial to cardiovascular health and it is important to understand the training methods that are the most beneficial. In particular we aim to determine if brief maximal exercise improves the function and stiffness of blood vessels and enhance blood vessel repair. Two methods of exercising are being compared, exercise bouts involving intermittent exercise and exercise completed all at once, but at a very high intensity.
Not Provided
Interventional
Not Applicable
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: None (Open Label)
Primary Purpose: Prevention
Exercise Anaphylaxis
  • Behavioral: Sprint interval exercise
    3 session per week of exercise on a exercise cycle ergometer. Each session involves 30s of maximal exercise followed by 4.5 min of easy cycling at 10W. This is repeated 4 times at each exercise session.
    Other Name: high intensity exercise training
  • Behavioral: Maximal continuous exercise
    3 sessions per week of an exercise intervention involving maximal cycling until the participant has completed an amount of work equivalent to a sprint interval training session. This exercise lasts between 3 and 3.5 minutes.
    Other Name: high intensity exercise training
  • Experimental: Interval maximal exercise
    Interval exercise involving repeated Wingate tests (30s durations of maximal exercise on a cycle ergometer).
    Intervention: Behavioral: Sprint interval exercise
  • Experimental: Continuous maximal exercise
    Continuous exercise of maximal exertion that has been work matched to an initial bout of interval exercise of 4 x 30s of maximal exercise. This exercise is performed on a cycle ergometer.
    Intervention: Behavioral: Maximal continuous exercise
Not Provided

*   Includes publications given by the data provider as well as publications identified by ClinicalTrials.gov Identifier (NCT Number) in Medline.
 
Unknown status
12
Same as current
November 2012
September 2012   (Final data collection date for primary outcome measure)

Inclusion Criteria:

  • Young healthy females
  • Between 18-25 years old
  • No on medication (this includes contraceptives)

Exclusion Criteria:

  • Medication use (including oral contraceptives)
  • Amenorrhoea
  • High blood pressure
  • Very active (>3 hours per week of organized physical activity)
Sexes Eligible for Study: Female
18 Years to 25 Years   (Adult)
Yes
Contact information is only displayed when the study is recruiting subjects
United Kingdom
 
 
NCT01314573
BIOSCI-10-007
Yes
Not Provided
Not Provided
Dr. Karen Birch, University of Leeds, Sport and Exercise Science
University of Leeds
Not Provided
Principal Investigator: Karen M Birch, BSc PhD University of Leeds
University of Leeds
March 2011

ICMJE     Data element required by the International Committee of Medical Journal Editors and the World Health Organization ICTRP