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Influence of Clonidine on Thrombozytes of Blood of Patients Under Anticoagulation Therapy With ASS and Clopidogrel

The recruitment status of this study is unknown. The completion date has passed and the status has not been verified in more than two years.
Verified March 2011 by Goethe University.
Recruitment status was:  Recruiting
Sponsor:
ClinicalTrials.gov Identifier:
NCT01314235
First Posted: March 14, 2011
Last Update Posted: March 14, 2011
The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details.
Information provided by:
Goethe University
March 8, 2011
March 14, 2011
March 14, 2011
October 2010
Not Provided
Numbers of participants with an activated area under the curve in ASPI test [ Time Frame: 30 minutes ]
Blood of patients under ASS and clopidogrel will show an activated platelet aggregation due to titrated clonidine in ASPI test, i.e. an activated area under the curve in Multiplate analysis.
Same as current
No Changes Posted
Numbers of participants with an activated area under the curve in TRAP test and ADP test [ Time Frame: 30 minutes ]
Blood of patients under ASS and clopidogrel will show an activated platelet aggregation due to titrated clonidine in TRAP test and ADP test, i.e. an activated area under the curve in Multiplate analysis.
Same as current
Not Provided
Not Provided
 
Influence of Clonidine on Thrombozytes of Blood of Patients Under Anticoagulation Therapy With ASS and Clopidogrel
The Influence of Clonidine on the Thrombozytes of Patients Under Double Anticagulation With ASS and Clopidogrel - an in Vitro Study

Clonidin works as a presynaptic agonist of alpha-sympathomimetic receptors of the brain but also in many other tissues. It is part of balanced anesthesia in general anesthesiology as well as a sedastive agent in intensive care units, but also serves as a third-line agent in many psychiatric diseases including ADHD, schizophrenia and PTSD.

The investigators want to show whether clonidin has an procoagulatoric effect on thrombozytes of patients under double anticoagulaotirc treatment with ASS and clopidogrel. The investigators will use a flowcytometric assay to determine activation of thrombozytes when they come into contact with clonidine in vitro as well as Multiplate analyses to determine activation of thrombozytes, either thrombin.induced aggregation, ADP-induced aggregation or arachidonic acid-induced aggregation of thrombozytes.

Not Provided
Observational
Time Perspective: Prospective
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Non-Probability Sample
patients going under vascular surgery with anticagulation with both ASS and clopidogrel
Anticoagulation
Not Provided
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*   Includes publications given by the data provider as well as publications identified by ClinicalTrials.gov Identifier (NCT Number) in Medline.
 
Unknown status
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Inclusion Criteria:

  • Elective vascular surgical patients with long-term medication (at least 5 days) with ASS and clopidogrel
  • Age above 18 years

Exclusion Criteria:

  • Additional anticoagulatoric treatment woth another inhibitor of platelet aggregation
  • Surgery within the last two weeks
  • Patients with long-term mediaction with omeprazole
  • Patients under hemodialysis
  • Patients with renal insufficiency (creatinine above 1.5mg/dl, urea above 80mg/dl)
  • Patients with hepatic dysfunction (GOT above 30U/I, GPT above 30 U/I, GLDH above 10 U/I)
  • Age under 18 yeary
  • Non-responder to ASS and / or clopidogrel
Sexes Eligible for Study: All
18 Years and older   (Adult, Senior)
Not Provided
Contact information is only displayed when the study is recruiting subjects
Germany
 
 
NCT01314235
Clonidinstudy
Not Provided
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Philipp Schmidt, Goethe University
Goethe University
Not Provided
Not Provided
Goethe University
March 2011