We updated the design of this site on September 25th. Learn more.
Show more
ClinicalTrials.gov
ClinicalTrials.gov Menu

Effect of Growth Hormone (GH) on Cardiac Echos in GH Deficient Patients After Acromegaly Treatment

This study has been completed.
Sponsor:
ClinicalTrials.gov Identifier:
NCT01302652
First Posted: February 24, 2011
Last Update Posted: March 18, 2015
The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details.
Information provided by (Responsible Party):
Karen Klahr Miller, MD, Massachusetts General Hospital
February 18, 2011
February 24, 2011
March 18, 2015
February 2011
February 2015   (Final data collection date for primary outcome measure)
Change from Baseline in Echocardiographic Findings at One Year [ Time Frame: baseline and one year ]
Same as current
Complete list of historical versions of study NCT01302652 on ClinicalTrials.gov Archive Site
Not Provided
Not Provided
Not Provided
Not Provided
 
Effect of Growth Hormone (GH) on Cardiac Echos in GH Deficient Patients After Acromegaly Treatment
Effects of Physiologic Growth Hormone Administration on Echocardiographic Parameters in Subjects With Growth Hormone Deficiency Following Cure of Acromegaly
The purpose of this research study is to study the effects of growth hormone (GH) replacement on the heart. The investigators will study these effects in people who have been cured of acromegaly and then have developed growth hormone deficiency (GHD, not enough growth hormone).
Not Provided
Observational
Observational Model: Case Control
Time Perspective: Prospective
Not Provided
Retention:   Samples Without DNA
Description:
serum and plasma
Non-Probability Sample
Men and women between age 18-75 who have developed growth hormone deficiency after history of acromegaly with biochemical cure.
Acromegaly
Not Provided
  • GH deficient after acromegaly cure (on GH replacement)
    Men and women with growth hormone deficiency following cure of acromegaly who are receiving growth hormone treatment.
  • GH deficient after acromegaly cure (not on GH replacement)
    Men and women with growth hormone deficiency following cure of acromegaly who are not receiving growth hormone treatment.
Not Provided

*   Includes publications given by the data provider as well as publications identified by ClinicalTrials.gov Identifier (NCT Number) in Medline.
 
Completed
20
February 2015
February 2015   (Final data collection date for primary outcome measure)

Inclusion Criteria:

  • age 18-75
  • history of acromegaly with biochemical cure
  • growth hormone deficiency

Exclusion Criteria:

  • untreated thyroid disease within the past 3 months
  • untreated adrenal insufficiency within the past 3 months
  • uncontrolled hypertension
  • congestive heart failure
  • gonadal steroid therapy within the past 3 months
  • pregnancy or nursing
Sexes Eligible for Study: All
18 Years to 75 Years   (Adult, Senior)
No
Contact information is only displayed when the study is recruiting subjects
United States
 
 
NCT01302652
2010P002188
No
Not Provided
Not Provided
Karen Klahr Miller, MD, Massachusetts General Hospital
Massachusetts General Hospital
Not Provided
Principal Investigator: Karen K Miller, MD Massachusetts General Hospital
Massachusetts General Hospital
March 2015