Triclosan Toothpaste and Third Molar Surgery

The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details. Identifier: NCT01292343
Recruitment Status : Completed
First Posted : February 9, 2011
Last Update Posted : October 28, 2015
Information provided by (Responsible Party):
Yanfang Ren, University of Rochester

February 4, 2011
February 9, 2011
October 28, 2015
February 2008
February 2013   (Final data collection date for primary outcome measure)
dry socket [ Time Frame: 3 to 7 days ]
Development of dry socket (alveolar osteitis) 3 to 7 days after tooth extraction
Same as current
Complete list of historical versions of study NCT01292343 on Archive Site
wound infection [ Time Frame: 3 to 7 days ]
Development of tooth extraction wound infection 3 to 7 days after extraction
Same as current
Not Provided
Not Provided
Triclosan Toothpaste and Third Molar Surgery
Effect of a Triclosan Containing Dentifrice on Oral Bacteria and Postoperative Complications Following Third Molar Surgery
Triclosan containing dentifrices are effective in the prevention of inflammatory complications following third molar surgery through reducing preoperative oral bacteria load.
This study may provide evidence on the effect of triclosan containing dentifrice on oral bacteria and oral inflammation prior to third molar surgery, and on the incidence of inflammatory complications after the surgery. If proven effective, dentifrice containing triclosan may be recommended prior to tooth extractions and replace antibiotics and other antimicrobial products as a prophylactic procedure before oral surgery procedures.
Not Applicable
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: Triple (Participant, Investigator, Outcomes Assessor)
Primary Purpose: Prevention
  • Dry Socket
  • Wound Infection
  • Other: Colgate Total Toothpaste
    Toothbrushing with Colgate Total Toothpaste
    Other Names:
    • triclosan
    • dentifrice
  • Other: Colgate Regular Toothpaste
    Toothbrushing with Colgate regular toothpaste
    Other Names:
    • fluoride
    • dentifrice
Not Provided
Not Provided

*   Includes publications given by the data provider as well as publications identified by Identifier (NCT Number) in Medline.
February 2013
February 2013   (Final data collection date for primary outcome measure)

Inclusion Criteria:

  • must include at least one mandibular third molar with partial or full bony impaction
  • no sign of active pericoronal (around the crown) infections
  • must have not taken antibiotics for any reason in the past 30 days
  • must be healthy and between 18 and 35 years of age
  • must be able to read and sign an informed consent

Exclusion Criteria:

  • Subjects with systemic diseases and pregnant or lactating women
  • Subjects with advanced periodontal diseases or having two or more untreated caries lesions
  • Subjects who cannot read and sign an informed consent
  • Subjects with signs of pericoronal infections
Sexes Eligible for Study: All
18 Years to 35 Years   (Adult)
Contact information is only displayed when the study is recruiting subjects
United States
Not Provided
Not Provided
Yanfang Ren, University of Rochester
University of Rochester
Not Provided
Principal Investigator: Yanfang Ren, DDS, MPH University of Rochester Eastman Dental Center
University of Rochester
October 2015

ICMJE     Data element required by the International Committee of Medical Journal Editors and the World Health Organization ICTRP