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New Echocardiographic Parameters for Assessment of Longitudinal Left Ventricular Function (LAX)

This study has been completed.
Sponsor:
Information provided by (Responsible Party):
Derliz Mereles, Heidelberg University
ClinicalTrials.gov Identifier:
NCT01275963
First received: January 12, 2011
Last updated: November 5, 2016
Last verified: November 2016
January 12, 2011
November 5, 2016
January 2011
October 2016   (Final data collection date for primary outcome measure)
left ventricular longitudinal systolic strain (LV-LSS) in all patients [ Time Frame: 2 years ]
left ventricular longitudinal systolic strain (LV-LSS) is measured in all patients by speckle tracking strain imaging
left ventricular longitudinal systolic strain (LV-LSS) [ Time Frame: 2 years ]
Complete list of historical versions of study NCT01275963 on ClinicalTrials.gov Archive Site
  • mitral annular plane systolic excursion (MAPSE) in all patients [ Time Frame: 2 years ]
    MAPSE is measured by M-Mode echocardiography
  • mitral annular systolic velocity (MASV) in all patients [ Time Frame: 2 years ]
    MASV is derived from tissue doppler
  • diastolic left ventricular function in all patients [ Time Frame: 2 years ]
    Diastolic function is assesed by mitral inflow, mitral annulus velocity, pulmonary vein flow and velocity of flow progression.
  • pulmonary artery systolic pressure (PASP) in all patients [ Time Frame: 2 years ]
    PASP is derived from Tricuspid valve regurgitation velocity
  • left ventricular ejection fraction (LVEF) in all patients [ Time Frame: 2 years ]
    EF is measured by modified Simpson's rule (biplane)
  • mitral annular plane systolic excursion (MAPSE) [ Time Frame: 2 years ]
  • mitral annular systolic velocity (MASV) [ Time Frame: 2 years ]
  • diastolic left ventricular function [ Time Frame: 2 years ]
    (assesed by mitral inflow, mitral annulus velocity, pulmonary vein flow and velocity of flow progression)
  • pulmonary artery systolic pressure (PASP) [ Time Frame: 2 years ]
  • left ventricular ejection fraction (LVEF) [ Time Frame: 2 years ]
    (by modified Simpson's rule)
Not Provided
Not Provided
 
New Echocardiographic Parameters for Assessment of Longitudinal Left Ventricular Function
New Echocardiographic Parameters for Assessment of Longitudinal Left Ventricular Function

Assessment of left ventricular systolic function is the most frequent indication for routine echocardiography. Qualitative eyeball method and biplane modified Simpson's rule, both measuring radial ventricular function, are the currently recommended methods to meet this challenge. Due to the complexity of the myocardial architecture, global left ventricular function also has longitudinal and torsional components.

The aim of this study is to evaluate new echocardiographic parameters for longitudinal left ventricular function. A special focus is set on strain imaging by speckle tracking, which is a relatively new technique. Patients with different cardiac pathologies (e. g. dilated cardiomyopathy, coronary artery disease, diastolic dysfunction) will be included and compared to healthy individuals.

Not Provided
Observational
Observational Model: Case Control
Time Perspective: Prospective
Not Provided
Not Provided
Non-Probability Sample
Healthy individuals and patients with various cardiac pathologies, who undergo routine echocardiography at our department
Cardiovascular Pathology
Not Provided
  • Control
    Healthy individuals without structural heart disease
  • CAD
    Patients with coronary artery disease
  • DCM
    Participants with dilated cardiomyopathy
  • HNCM
    Patients with hypertrophic non-obstructive cardiomyopathy
  • HOCM
    Patients with hypertrophic obstructive cardiomyopathy
  • RCM
    Patients with restrictive cardiomyopathy
  • Amyloidosis
    Patients with cardiac manifestation of amyloidosis
  • HFPEF
    Patients with heart failure with preserved ejection fraction (diastolic heart failure)
Aurich M, Keller M, Greiner S, Steen H, Aus dem Siepen F, Riffel J, Katus HA, Buss SJ, Mereles D. Left ventricular mechanics assessed by two-dimensional echocardiography and cardiac magnetic resonance imaging: comparison of high-resolution speckle tracking and feature tracking. Eur Heart J Cardiovasc Imaging. 2016 Dec;17(12):1370-1378. Epub 2016 Mar 24.

*   Includes publications given by the data provider as well as publications identified by ClinicalTrials.gov Identifier (NCT Number) in Medline.
 
Completed
400
October 2016
October 2016   (Final data collection date for primary outcome measure)

Inclusion Criteria:

  • persons of 18 years and older who receive a transthoracic echocardiography at our department
  • written consent

Exclusion Criteria:

  • permanent pacemaker rhythm
  • moderate/severe valvular heart disease
Sexes Eligible for Study: All
18 Years and older   (Adult, Senior)
Yes
Contact information is only displayed when the study is recruiting subjects
Germany
 
 
NCT01275963
S-401/2010
No
Not Provided
Not Provided
Derliz Mereles, Heidelberg University
Heidelberg University
Not Provided
Principal Investigator: Matthias Aurich, M.D. Heidelberg University
Principal Investigator: Derliz Mereles, M.D. Heidelberg University
Heidelberg University
November 2016

ICMJE     Data element required by the International Committee of Medical Journal Editors and the World Health Organization ICTRP