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Effect of Cisatracurium Versus Atracurium on Intraocular Pressure in Patients Underwent General Anesthesia

This study has been completed.
Sponsor:
ClinicalTrials.gov Identifier:
NCT01273831
First Posted: January 11, 2011
Last Update Posted: January 11, 2011
The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details.
Information provided by:
Isfahan University of Medical Sciences
January 10, 2011
January 11, 2011
January 11, 2011
July 2009
December 2009   (Final data collection date for primary outcome measure)
intraocular pressure [ Time Frame: at 2 minutes after intubation ]
determining intraocular pressure in atracurium and cisatracurium groups
Same as current
No Changes Posted
systolic blood pressure [ Time Frame: at 2 minutes after intubation ]
identification of systolic blood pressure in atracurium and cisatracurium groups
Same as current
Not Provided
Not Provided
 
Effect of Cisatracurium Versus Atracurium on Intraocular Pressure in Patients Underwent General Anesthesia
Study of Effects of Cisatracurium and Atracurium on Intraocular Pressure
The purpose of this study is to determine which drug makes lower intraocular pressure
Increase in intraocular pressure (IOP) following tracheal intubation during general anesthesia can be troublesome. The investigators compared the influence of cisatracurium and atracurium on IOP in patients undergoing general anesthesia.
Interventional
Phase 2
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: Single (Outcomes Assessor)
Intraocular Pressure
  • Drug: atracurium
    atracurium, Drop,0.5 mg/kg, one time, one day
  • Drug: cisatracurium
    cisatracurium, drop,0.15mg/kg,one time, one day
  • atracurium
    Patients who underwent general anesthesia received atracurium
    Intervention: Drug: atracurium
  • cisatracurium
    Patients who underwent general anesthesia received cisatracurium
    Intervention: Drug: cisatracurium
Not Provided

*   Includes publications given by the data provider as well as publications identified by ClinicalTrials.gov Identifier (NCT Number) in Medline.
 
Completed
90
December 2009
December 2009   (Final data collection date for primary outcome measure)

Inclusion Criteria:

ASA class of I or II baseline IOP of lower than 20 mmHg stable hemodynamics no history of ophthalmic diseases not using drugs affecting IOP (e.g. anticholinergics, sympathomimetics) no contraindication for atracurium or cisatracurium administration.

Exclusion Criteria:

difficulty in mask ventilation or in tracheal intubation end expiratory CO2 of below 35 mmHg or over 45 mmHg O2 saturation of below 90%

Sexes Eligible for Study: All
Child, Adult, Senior
Yes
Contact information is only displayed when the study is recruiting subjects
Iran, Islamic Republic of
 
 
NCT01273831
ASD-1213-10
Yes
Not Provided
Not Provided
Dr. Alireza Yousefy/Associate Professor of Medical Education, Isfahan University of Medical Sciences
Isfahan University of Medical Sciences
Not Provided
Study Chair: Mitra Jabalameri, A.Professor Associate Professor,Anesthesiology department
Isfahan University of Medical Sciences
July 2009

ICMJE     Data element required by the International Committee of Medical Journal Editors and the World Health Organization ICTRP