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Evaluation of the Proliferative Activities of Insulin Analogues in Primary Human Tumor Cells

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ClinicalTrials.gov Identifier: NCT01267461
Recruitment Status : Available
First Posted : December 28, 2010
Last Update Posted : August 10, 2012
Information provided by (Responsible Party):

December 27, 2010
December 28, 2010
August 10, 2012
Evaluation of the Proliferative Activities of Insulin Analogues in Primary Human Tumor Cells
Recently the general medical literature has become aware that the use of certain long-acting insulin analogues could potentially increase cancer risk.During the last few years the investigators group generated information of both scientific and clinical relevance on the proliferative and anti-apoptotic actions of insulin analogues. The goal of this project is to evaluate the hypothesis that the proliferative and signalling activities elicited by insulin analogues may have a impact on tumor behavior. In this study the investigators will asses the biological actions of insulin analogs in primary tumor cells of endometrial and colon cancer.
Not Provided
Expanded Access
Other: Tissue sample from tumor
Endometrial cancer specimens will be obtained from patients operated and treated at the Gynecologic Oncology Unit at Meir Medical Center. Colon cancer specimens will be obtained from patients that underwent colonoscopy at the Gastrointestinal Department at Meir Medical Center.
Not Provided
Contact: Ilan Bruchim, MD 972-9-7472561 ilan.bruchim@clalit.org.il
Not Provided
Meir Medical Center
Meir Medical Center
Tel Aviv University
Not Provided
Meir Medical Center
August 2012