We updated the design of this site on December 18, 2017. Learn more.
ClinicalTrials.gov
ClinicalTrials.gov Menu

Quantification of Human Adipogenesis

The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details.
ClinicalTrials.gov Identifier: NCT01257997
Recruitment Status : Active, not recruiting
First Posted : December 10, 2010
Last Update Posted : August 26, 2016
Sponsor:
Information provided by (Responsible Party):

December 9, 2010
December 10, 2010
August 26, 2016
December 2010
December 2016   (Final data collection date for primary outcome measure)
Quantifying human adipogenesis-counting the number of new fat cells. [ Time Frame: 4 weeks-7 months ]
Quantifying human adipogenesis-counting the number of new fat cells. [ Time Frame: 4 weeks ]
Complete list of historical versions of study NCT01257997 on ClinicalTrials.gov Archive Site
Not Provided
Not Provided
Not Provided
Not Provided
 
Quantification of Human Adipogenesis
Quantification of Human Adipogenesis
This pilot study is using a novel technology to measure the rate of turnover of new fat cells. Analysis of volunteer samples is ongoing, however the study is currently not enrolling new volunteers.
Not Provided
Observational
Time Perspective: Prospective
Not Provided
Retention:   Samples Without DNA
Description:
Fat biopsy. Oral mucosal smear. White blood cells.
Non-Probability Sample
Healthy volunteers. Aged 18-49 years. Free of significant chronic medical illness. Free of illicit substance abuse.
Healthy
Biological: 15N-Thymidine, 2H-Water

Stable isotope 15N-thymidine, infused IV (15mg/hour) for 72 hours (phase 1 pilot).

Stable isotope 2H-water, ingested by mouth once per day for 3 days (phase 1 pilot) or 28 days (phase 2 pilot).

Healthy subjects
18-49 year old healthy men and women. Free of significant chronic medical illness and illicit substance abuse. Body mass index from 20 to 27.
Intervention: Biological: 15N-Thymidine, 2H-Water
Steinhauser ML, Bailey AP, Senyo SE, Guillermier C, Perlstein TS, Gould AP, Lee RT, Lechene CP. Multi-isotope imaging mass spectrometry quantifies stem cell division and metabolism. Nature. 2012 Jan 15;481(7382):516-9. doi: 10.1038/nature10734.

*   Includes publications given by the data provider as well as publications identified by ClinicalTrials.gov Identifier (NCT Number) in Medline.
 
Active, not recruiting
20
December 2017
December 2016   (Final data collection date for primary outcome measure)

Inclusion Criteria:

  • Aged 18-49 years.
  • Healthy.

Exclusion Criteria:

  • Significant chronic medical illness.
  • Illicit substance or alcohol abuse.
  • Body mass index > 27 kg/meters squared.
  • Underweight (BMI < 20 kg/m2).
  • History of keloid formation (excessive scarring).
  • Pregnant.
Sexes Eligible for Study: All
18 Years to 49 Years   (Adult)
Yes
Contact information is only displayed when the study is recruiting subjects
United States
 
 
NCT01257997
BWH-2010p001900
No
Not Provided
Not Provided
Matthew Steinhauser, MD, Brigham and Women's Hospital
Brigham and Women's Hospital
Not Provided
Principal Investigator: Matthew L Steinhauser, MD Brigham and Women's Hospital
Brigham and Women's Hospital
August 2016