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Long-term Caloric Restriction and Cellular Aging Markers (CRONA)

This study has been completed.
Sponsor:
ClinicalTrials.gov Identifier:
NCT01256840
First Posted: December 9, 2010
Last Update Posted: October 13, 2017
The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details.
Collaborator:
Robert Wood Johnson Foundation
Information provided by (Responsible Party):
University of California, San Francisco
December 2, 2010
December 9, 2010
May 12, 2017
October 13, 2017
October 13, 2017
December 2010
August 2014   (Final data collection date for primary outcome measure)
Telomere Length [ Time Frame: One day ]
This study is not a clinical trial, but the UCSF Committee on Human Research requires registration with clinicaltrials.gov. It is a ONE TIME POINT study, where we get a simple blood draw from people from three groups - calorie restricting, normal eating, and obese. Therefore, there IS NO FOLLOW UP/time frame. The outcome measure is assessed on the day of the study. Telomere length is a marker of cellular aging and is used to understand how the cells are aging. We will investigate whether long-term caloric restriction is associated cross-sectionally with longer telomere length (less aging).
Same as current
Complete list of historical versions of study NCT01256840 on ClinicalTrials.gov Archive Site
Not Provided
Not Provided
Not Provided
Not Provided
 
Long-term Caloric Restriction and Cellular Aging Markers
Caloric Restriction With Optimal Nutrition and Aging Study
The purpose of this study is to see whether people who have restricted the number of calories they eat for a long period of time, compared to normal-eating and obese people, have markers of cellular aging that look younger.
Not Provided
Observational
Observational Model: Cohort
Time Perspective: Cross-Sectional
Not Provided
Retention:   Samples With DNA
Description:
Whole blood, serum.
Non-Probability Sample
Community sample and Calorie Restriction Society
Aging
Not Provided
  • Calorie Restricting Group
  • Normal-eating controls
  • Obese comparison group

*   Includes publications given by the data provider as well as publications identified by ClinicalTrials.gov Identifier (NCT Number) in Medline.
 
Completed
71
August 2014
August 2014   (Final data collection date for primary outcome measure)

Inclusion Criteria:

  • Calorie restricting group: Self-reported caloric restriction for at least two years
  • Calorie restriction group: BMI below 23
  • Normal eating control: Normal eating (no history of caloric restriction) for two years
  • Normal eating control: BMI below 30
  • Obese comparison group: BMI above 30
  • Obese comparison group: Normal eating (no history of caloric restriction) for two years

Exclusion Criteria:

  • Regular smoker for the past six months
Sexes Eligible for Study: All
18 Years and older   (Adult, Senior)
Yes
Contact information is only displayed when the study is recruiting subjects
United States
 
 
NCT01256840
UCSF-CHR-10-01323
No
Not Provided
Not Provided
University of California, San Francisco
University of California, San Francisco
Robert Wood Johnson Foundation
Principal Investigator: A. Janet Tomiyama, Ph.D. University of California, San Francisco
University of California, San Francisco
October 2017