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Pain and Schizophrenia

This study has been terminated.
(recruitment difficulties)
Sponsor:
Information provided by (Responsible Party):
University Hospital, Strasbourg, France
ClinicalTrials.gov Identifier:
NCT01244542
First received: November 17, 2010
Last updated: August 19, 2016
Last verified: August 2016

November 17, 2010
August 19, 2016
August 2011
January 2015   (final data collection date for primary outcome measure)
  • Unpleasant stimuli [ Time Frame: during experimental session ] [ Designated as safety issue: No ]
    acute electrical stimulation
  • Unpleasant stimuli [ Time Frame: during experimental session ] [ Designated as safety issue: No ]
    emotional pictures
Not Provided
Complete list of historical versions of study NCT01244542 on ClinicalTrials.gov Archive Site
Not Provided
Not Provided
Not Provided
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Pain and Schizophrenia
Pain and Schizophrenia
The aim of the investigators project is to explore the mechanisms of pain insensitivity in patients with schizophrenia, in order to prevent its invalidating consequences. The investigators will couple methods of experimental psychology with EEG and blood samplings, in order to distinguish the role of non-painful perception, attention, aversive effects, and pain expression, and the investigators will explore an original neurobiological hypothesis regarding the activation of opioid receptors.
Not Provided
Interventional
Not Provided
Allocation: Non-Randomized
Endpoint Classification: Pharmacodynamics Study
Intervention Model: Parallel Assignment
Masking: Open Label
Primary Purpose: Health Services Research
  • Pain
  • Schizophrenia
Other: unpleasant stimuli
  • Experimental: Patients with schizophrenia
    Intervention: Other: unpleasant stimuli
  • Active Comparator: Healthy controls
    controls matched with patients on age, sex and education level
    Intervention: Other: unpleasant stimuli
Not Provided

*   Includes publications given by the data provider as well as publications identified by ClinicalTrials.gov Identifier (NCT Number) in Medline.
 
Terminated
83
January 2015
January 2015   (final data collection date for primary outcome measure)

Inclusion Criteria:

  • Patients with schizophrenia (criteria DSM IV) or healthy controls matched with patients on age, sex and education level
  • 18-55 years old

Exclusion Criteria:

  • Past history affecting CNS
  • Intake of psychotropic drugs, except for patients
  • Metabolic disorder affecting sensory processing (diabetes)
  • Intake of benzodiazepines
Both
18 Years to 55 Years   (Adult)
Yes
Contact information is only displayed when the study is recruiting subjects
France
 
NCT01244542
4706
No
Not Provided
Not Provided
University Hospital, Strasbourg, France
University Hospital, Strasbourg, France
Not Provided
Study Director: Anne Giersch, MD University Hospital, Strasbourg, France
University Hospital, Strasbourg, France
August 2016

ICMJE     Data element required by the International Committee of Medical Journal Editors and the World Health Organization ICTRP