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Development of New MRI Pulse Sequences for Probing Lung Function in Volunteers With Hyperpolarised 3He Gas

This study is currently recruiting participants.
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Verified May 2017 by Sheffield Teaching Hospitals NHS Foundation Trust
Sponsor:
Collaborator:
University of Sheffield
Information provided by (Responsible Party):
Sheffield Teaching Hospitals NHS Foundation Trust
ClinicalTrials.gov Identifier:
NCT01235494
First received: November 4, 2010
Last updated: May 4, 2017
Last verified: May 2017
November 4, 2010
May 4, 2017
July 2010
December 2018   (Final data collection date for primary outcome measure)
Not Provided
Not Provided
Complete list of historical versions of study NCT01235494 on ClinicalTrials.gov Archive Site
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Development of New MRI Pulse Sequences for Probing Lung Function in Volunteers With Hyperpolarised 3He Gas
Development of New MRI Pulse Sequences for Probing Lung Function in Volunteers With Hyperpolarised 3He Gas
To develop techniques with MRI of Helium-3 gas to give functional images of the lungs. The goal is to test a single breath-hold functional 3-He MRI pulse sequence with sensitivity to multiple functional aspects of the luncg physiology. A group of 20 healthy volunteers willbe recruited from the local research group and the results compared with existing methods that require seperate breath-holds of 3He gas
Not Provided
Interventional
Phase 1
Intervention Model: Single Group Assignment
Masking: No masking
Primary Purpose: Other
Healthy Volunteers
Other: polarised 3 helium
1 inhalation (= 1 litre)
Experimental: polarised 3 helium
inhaled gas
Intervention: Other: polarised 3 helium
Not Provided

*   Includes publications given by the data provider as well as publications identified by ClinicalTrials.gov Identifier (NCT Number) in Medline.
 
Recruiting
20
December 2018
December 2018   (Final data collection date for primary outcome measure)

Inclusion Criteria:

  • age 18 -70

Exclusion Criteria:

  • contraindication to MRI
  • Resting oxygen saturation <95%
  • Volunteers requiring bronchodilators less than 4 hourly
  • additional respiratory diagnoses
  • pregnancy
Sexes Eligible for Study: All
18 Years to 70 Years   (Adult, Senior)
Yes
United Kingdom
 
 
NCT01235494
STH15080
No
Not Provided
Not Provided
Sheffield Teaching Hospitals NHS Foundation Trust
Sheffield Teaching Hospitals NHS Foundation Trust
University of Sheffield
Not Provided
Sheffield Teaching Hospitals NHS Foundation Trust
May 2017

ICMJE     Data element required by the International Committee of Medical Journal Editors and the World Health Organization ICTRP