Study Using Plasma for Patients Requiring Emergency Surgery (SUPPRES)
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|ClinicalTrials.gov Identifier: NCT01221389|
Recruitment Status : Unknown
Verified July 2011 by Ottawa Hospital Research Institute.
Recruitment status was: Recruiting
First Posted : October 15, 2010
Last Update Posted : July 21, 2011
|First Submitted Date ICMJE||August 19, 2010|
|First Posted Date ICMJE||October 15, 2010|
|Last Update Posted Date||July 21, 2011|
|Start Date ICMJE||March 2011|
|Estimated Primary Completion Date||December 2012 (Final data collection date for primary outcome measure)|
|Current Primary Outcome Measures ICMJE
||Percentage of eligible participants who were recruited and randomized to full participation in trial as a measure of future success completion of a larger multicenter trial. [ Time Frame: 24 hours ]
The ability to randomize patients and have them receive AB+ plasma or colloid control early in their emergency surgery.
|Original Primary Outcome Measures ICMJE||Same as current|
|Change History||Complete list of historical versions of study NCT01221389 on ClinicalTrials.gov Archive Site|
|Current Secondary Outcome Measures ICMJE
|Original Secondary Outcome Measures ICMJE||Same as current|
|Current Other Outcome Measures ICMJE||Not Provided|
|Original Other Outcome Measures ICMJE||Not Provided|
|Brief Title ICMJE||Study Using Plasma for Patients Requiring Emergency Surgery|
|Official Title ICMJE||Study Using Plasma for Patients Requiring Emergency Surgery: A Randomized Pilot Trial of Early Plasma for Patients Undergoing Emergency Surgery for Hemorrhagic Shock|
Information on the management of casualties from the ongoing conflicts in Afghanistan and Iraq has brought in to question the traditional approach to blood transfusion in hemorrhaging patients. Present recommendations for when to transfuse plasma products is when coagulation tests become abnormal. The proposed trial will investigate whether the more aggressive plasma transfusion strategies as advocated from researchers based on the Central Asian conflicts is valid. Since a study to determine the full impact of an altered plasma transfusion practice would require thousands of patients, a feasibility trial is appropriate and is being proposed. The hypotheses are thus:
Primary Hypothesis- A multicentre trial that investigates the earlier use of plasma in patients with hemorrhagic shock going for emergency surgery will be feasible.
Secondary Hypotheses- The early use of a universal donor blood plasma (AB+ plasma) in patients with shock due to blood loss (i.e. hemorrhagic) going for emergency surgery will reduce overall exposure to the total number of blood donor products (so-called allogeneic blood exposure). A reduction in allogeneic blood exposure would then reduce the total number of blood transfusion-related complications. The early use of this plasma product is safe and will not increase the incidence of blood clotting or other transfusion-related complications.
Investigations that have arisen from reviews of casualty management in the ongoing conflicts in Afghanistan and Iraq have challenged the standard approach to blood transfusion in hemorrhaging patients. Present recommendations are to ideally transfuse non-red blood cell blood products as indicated by coagulation and other blood tests. In the event that testing is not available or feasible, then clinical judgment is advised with two recommendations. The first is that platelets are usually required after red blood cell (RBC) transfusions of one blood volume (approximately 5 liters of blood loss); and the second is that plasma is not usually required until RBC transfusion of well over one blood volume. Contrary to these recommendations is evidence from these conflicts indicating that delays in plasma transfusion or reduced plasma dosing are associated with increased mortality. Although the evidence is primarily retrospective and at times circumstantial in nature, the relationship between plasma administration and mortality appears to be causation rather than simple association. Matching of injury severity and other important variables does not alter this conclusion. If this conclusion is true, the question becomes whether or not the transfusion practice of patients in a civilian setting should be changed.
The present plasma transfusion recommendations were largely based on studies of plasma exchange patients and the use of data from the 1970's. In plasma exchange, patients have a controlled removal of their plasma that is ultimately replaced with donor plasma. Coagulopathy develops solely from the amount of plasma removal since no consumption of factors exists. Hemorrhaging patients however lose coagulation factors both in shed blood and due to ongoing consumption at sites of injury. Further, the hemodynamic instability and hypovolemia experienced by hemorrhaging patients further exacerbates the reduction in clotting factor levels. Prior to the late 1980's, hemorrhaging patients often received whole blood transfusions. Whole blood, no longer used in most circumstances, contains approximately 1 unit of plasma in each unit. Thus, patients receiving whole blood will not develop a coagulopathy as quickly as patients who receive the now standard packed red blood cell units.
Despite a lack of prospective studies and significant limitations of the supporting evidence, the practice of waiting to administer plasma was rapidly adopted. Reasons for this were several but included concerns about infectious transmissions, shortage of blood products and the financial costs of the blood products. Regardless of the reasons for their development however, the present transfusion recommendations including those for plasma may no longer be applicable in all circumstances.
A strong argument against waiting for the coagulopathy to develop before treating is that the consequences of the coagulopathy are so grave that they should be avoided. The coagulopathy of hemorrhagic shock is a major component of the 'lethal triad' seen in hemorrhaging patients (in conjunction with acidosis and hypothermia). The lethal triad has a very high mortality rate (over 70%) with limited ability of physicians to treat it. Evidence supporting this argument has primarily come from the conflicts in Central Asia. Several retrospective studies have been published by the US Army Institute of Surgical Research that have not only challenged this practice but have resulted in changes in how the US armed forces manage trauma patients. The US military now uses plasma in a 1:1 ratio in their traumatized soldiers (i.e. 1 unit of plasma given for every unit of packed RBC).
Major hemorrhagic injuries in non-military situations consist primarily of traumatic injuries and major blood vessel (i.e. vascular) injuries. Although all of these injuries or problems are not exactly the same as military casualties, there are major commonalities between these population groups that allow the results of the military studies to be applicable to these civilian populations. Retrospective and case-control trials in non-military trauma and in ruptured abdominal aortic aneurysms (AAA) offer indirect evidence to support a different plasma transfusion practice that is more akin to the military recommendations. Computer simulations to model massive blood transfusion scenarios also gives credence to the premise that traditional transfusion practice is incorrect for actively hemorrhaging patients and advocates the earlier use of plasma.
A retrospective chart review of 5 years of the perioperative management of Priority 1 AAA ruptures at The Ottawa Hospital was conducted with research ethics board approval. Of 145 reviewed cases, there was a 64% survival rate. The use of plasma occurred in over 75% of patients and over 99% of patients were exposed to allogeneic blood products. Plasma use was associated with poor outcomes and served as a marker for cases with higher blood loss and blood product exposure. The use of plasma was however consistent with the present recommendations and thus appeared to be reactive in nature, rather than proactive use.
A definitive trial that assesses the role of early plasma has not been performed. Unfortunately, a study to determine the full impact of an altered plasma transfusion practice would require thousands of patients. The emergency nature of these surgical patients would also make the ability to randomize patients challenging. The goal of the present trial will therefore be to assess the feasibility of such a trial. We need to assess the ability to randomize patients, to prepare plasma and deliver it in a timely fashion. Further, the logistics of having physicians to administer the study fluid (i.e. plasma or colloid control) in a timely fashion will be determined. Finally, the ability to accurately measure outcomes will be assessed.
|Study Type ICMJE||Interventional|
|Study Phase||Phase 4|
|Study Design ICMJE||Allocation: Randomized
Intervention Model: Single Group Assignment
Masking: Triple (Participant, Investigator, Outcomes Assessor)
Primary Purpose: Treatment
|Intervention ICMJE||Drug: Human Plasma
Patients will receive either 2 units of AB+ plasma or 2 units of hydroxyethylated starch control solution once they are sent to the OR for emergency surgery to address etiology for hemorrhagic shock.
Other Name: non applicable
|Publications *||Not Provided|
* Includes publications given by the data provider as well as publications identified by ClinicalTrials.gov Identifier (NCT Number) in Medline.
|Recruitment Status ICMJE||Unknown status|
|Estimated Enrollment ICMJE||40|
|Estimated Completion Date||December 2012|
|Estimated Primary Completion Date||December 2012 (Final data collection date for primary outcome measure)|
|Eligibility Criteria ICMJE||
|Ages||18 Years and older (Adult, Senior)|
|Accepts Healthy Volunteers||No|
|Contacts ICMJE||Contact information is only displayed when the study is recruiting subjects|
|Listed Location Countries ICMJE||Canada|
|Removed Location Countries|
|NCT Number ICMJE||NCT01221389|
|Other Study ID Numbers ICMJE||OHREB#2010077-01H|
|Has Data Monitoring Committee||No|
|U.S. FDA-regulated Product||Not Provided|
|IPD Sharing Statement||Not Provided|
|Responsible Party||Dr David Neilipovitz, The Ottawa Hospital|
|Study Sponsor ICMJE||Ottawa Hospital Research Institute|
|Collaborators ICMJE||Not Provided|
|PRS Account||Ottawa Hospital Research Institute|
|Verification Date||July 2011|
ICMJE Data element required by the International Committee of Medical Journal Editors and the World Health Organization ICTRP