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Attenuation of Pain in Men and Women

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ClinicalTrials.gov Identifier: NCT01220414
Recruitment Status : Completed
First Posted : October 13, 2010
Results First Posted : February 16, 2018
Last Update Posted : February 16, 2018
Sponsor:
Information provided by (Responsible Party):
University of Wisconsin, Madison

September 28, 2010
October 13, 2010
December 7, 2015
February 16, 2018
February 16, 2018
September 2010
January 2013   (Final data collection date for primary outcome measure)
Time for Subject to Reach Pain Threshold [ Time Frame: Baseline ]
Pain threshold, pain ratings, and temporal summation [ Time Frame: Before and immediately following an exercise session ]
Complete list of historical versions of study NCT01220414 on ClinicalTrials.gov Archive Site
Not Provided
Not Provided
Not Provided
Not Provided
 
Attenuation of Pain in Men and Women
Attenuation of Pain in Men and Women: Mechanisms of Exercise-Induced Analgesia
The purpose of this study is to examine opioid and endocannabinoid mechanisms of exercise-induced analgesia in men and women.
Not Provided
Interventional
Not Applicable
Allocation: Randomized
Intervention Model: Crossover Assignment
Masking: Double (Participant, Investigator)
Primary Purpose: Basic Science
Pain
  • Drug: Naltrexone, then placebo
    50 mg of naltrexone
  • Drug: Placebo, then Naltrexone
    sugar pill
  • Active Comparator: Men
    Interventions:
    • Drug: Naltrexone, then placebo
    • Drug: Placebo, then Naltrexone
  • Active Comparator: Women
    Interventions:
    • Drug: Naltrexone, then placebo
    • Drug: Placebo, then Naltrexone
Not Provided

*   Includes publications given by the data provider as well as publications identified by ClinicalTrials.gov Identifier (NCT Number) in Medline.
 
Completed
60
Same as current
January 2013
January 2013   (Final data collection date for primary outcome measure)

Inclusion Criteria: Healthy men and women

Exclusion Criteria:

  • current cardiac or other chronic diseases (e.g., cancer, diabetes, hypertension, kidney disease); routine use of prescriptive medications; history of vasovagal response to phlebotomy; an allergy to naltrexone; pregnancy; current smokers; current use of recreational drugs; history of substance abuse
Sexes Eligible for Study: All
18 Years to 40 Years   (Adult)
Yes
Contact information is only displayed when the study is recruiting subjects
United States
 
 
NCT01220414
H-2010-0087
Yes
Not Provided
Not Provided
University of Wisconsin, Madison
University of Wisconsin, Madison
Not Provided
Not Provided
University of Wisconsin, Madison
January 2018

ICMJE     Data element required by the International Committee of Medical Journal Editors and the World Health Organization ICTRP