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Environmental & Genetic Influences on Vitamin D Status

This study has been completed.
Sponsor:
ClinicalTrials.gov Identifier:
NCT01208636
First Posted: September 24, 2010
Last Update Posted: September 24, 2010
The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details.
Collaborator:
Procter and Gamble
Information provided by:
Creighton University
August 30, 2010
September 24, 2010
September 24, 2010
August 2010
August 2010   (Final data collection date for primary outcome measure)
25(OH)D levels [ Time Frame: 1 month ]
25(OH)D levels were measured at the only visit
Same as current
No Changes Posted
Genetic testing of 13 candidate genes [ Time Frame: 1 month ]
13 candidate genes were tested and their relationship to 25(OH)D examined.
Same as current
Not Provided
Not Provided
 
Environmental & Genetic Influences on Vitamin D Status
Environmental & Genetic Influences on Vitamin D Status
The purpose of this study is to determine the effect of environmental and genetic influences on Vitamin D status.
Vitamin D deficiency is a common problem. The principal source of vitamin D for humans is solar exposure, with cutaneous synthesis of vitamin D by photoconversion of 7-dehydrocholesterol in the skin to pre-vitamin D3. Latitude, altitude, season, skin pigmentation, and age are recognized factors that influence how much vitamin D can be made by solar exposure. Surprisingly, Vitamin D deficiency has been described in people dwelling in southern Florida and in surfers in Hawaii. We hypothesize that genetic variations in vitamin metabolism accounts for these differences.
Observational
Observational Model: Cohort
Time Perspective: Cross-Sectional
Not Provided
Retention:   Samples With DNA
Description:
Blood was obtained for genetic testing of selected 13 candidate genes important for vitamin D metabolism
Non-Probability Sample

This study will include 50 "healthy" unrelated community dwelling males or females.

The subjects will be between ages 18-60.

Vitamin D Deficiency
Not Provided
Sun exposed people
Sun exposure >3 hours daily for at least 5 days weekly for the last 3 months.
Not Provided

*   Includes publications given by the data provider as well as publications identified by ClinicalTrials.gov Identifier (NCT Number) in Medline.
 
Completed
40
August 2010
August 2010   (Final data collection date for primary outcome measure)

Inclusion Criteria:

  • Able to consent and come for a study visit.
  • Male or female between ages 18-60.
  • Sun exposure >3 hours daily for at least 5 days weekly for the last 3 months.

Exclusion Criteria:

  • Unable to consent or come to a visit
  • Taking Vitamin D supplements, anticonvulsants, barbiturates, steroids, having granulomatous disease, or liver or kidney disease as these medications and conditions interfere with Vitamin D metabolism.
  • Related to another participant by blood.
Sexes Eligible for Study: All
18 Years to 60 Years   (Adult)
Yes
Contact information is only displayed when the study is recruiting subjects
United States
 
 
NCT01208636
Creighton9
No
Not Provided
Not Provided
Laura Armas, Creighton University
Creighton University
Procter and Gamble
Principal Investigator: Laura Armas, MD Creighton University
Creighton University
September 2010