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Effect of Ambient Light on the Parameters of the Pupillary Light Reflex

The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details.
 
ClinicalTrials.gov Identifier: NCT01207817
Recruitment Status : Completed
First Posted : September 23, 2010
Last Update Posted : September 23, 2010
Sponsor:
Information provided by:
Rutgers, The State University of New Jersey

Tracking Information
First Submitted Date January 25, 2010
First Posted Date September 23, 2010
Last Update Posted Date September 23, 2010
Study Start Date September 2009
Actual Primary Completion Date February 2010   (Final data collection date for primary outcome measure)
Current Primary Outcome Measures
 (submitted: September 22, 2010)
pupillary light reflex: amplitude, latency, maximum constriction velocity, mean constriction velocity and dilation velocity during different levels of ambient light [ Time Frame: Pupillometry readings will be taken at 3 potential light readings low light, intermediate light and high ambient light. A total of 48 readings will be done. All parameters will be done at one sitting and will take approximately 45 minutes to complete. ]
Original Primary Outcome Measures Same as current
Change History No Changes Posted
Current Secondary Outcome Measures Not Provided
Original Secondary Outcome Measures Not Provided
Current Other Pre-specified Outcome Measures Not Provided
Original Other Pre-specified Outcome Measures Not Provided
 
Descriptive Information
Brief Title Effect of Ambient Light on the Parameters of the Pupillary Light Reflex
Official Title Effect of Ambient Light on the Parameters of the Pupillary Light Reflex
Brief Summary The purpose of this study is to determine the effects of varying luminescent levels on the pupillary response.
Detailed Description Evaluation of the pupillary response is an underemphasized aspect of the assessment of visual function. The pupillary light reflex is one of the few objective indicators of afferent input from the retina and optic nerve. Since the pupillary light reflex is processed through the retina, it may be used to assess visual integrity (1). Pupillometry is a reliable technology capable of providing repetitive data on quantitative pupillary function in states of health and disease (2). Amplitude, latency, maximum constriction velocity, mean constriction velocity, and dilation velocity are measured using the Neuroleptics pupillometer. The effects of varying levels of ambient light on these parameters of the pupillary response have not been extensively studied. The purpose of this investigation is to determine the effects of varying luminescent levels on the pupillary response.
Study Type Observational
Study Design Observational Model: Case Control
Time Perspective: Prospective
Target Follow-Up Duration Not Provided
Biospecimen Not Provided
Sampling Method Non-Probability Sample
Study Population Healthy volinteers
Condition Healthy Volunteers
Intervention Other: Pupillometry
Pupillometry readings will be taken at low, intermediate and high ambient light
Study Groups/Cohorts no condition
no condition - healthy volunteers
Intervention: Other: Pupillometry
Publications * Not Provided

*   Includes publications given by the data provider as well as publications identified by ClinicalTrials.gov Identifier (NCT Number) in Medline.
 
Recruitment Information
Recruitment Status Completed
Estimated Enrollment
 (submitted: September 22, 2010)
30
Original Estimated Enrollment Same as current
Actual Study Completion Date February 2010
Actual Primary Completion Date February 2010   (Final data collection date for primary outcome measure)
Eligibility Criteria

Inclusion Criteria:

  • healthy volunteers

Exclusion Criteria:

  • recent bout of conjunctivitis or infection in the eye recent eye surgery seizure disorder unable to lie flat for 30 minutes known history of eye disease which cannot be corrected with lenses
Sex/Gender
Sexes Eligible for Study: All
Ages 18 Years to 65 Years   (Adult, Older Adult)
Accepts Healthy Volunteers Yes
Contacts Contact information is only displayed when the study is recruiting subjects
Listed Location Countries United States
Removed Location Countries  
 
Administrative Information
NCT Number NCT01207817
Other Study ID Numbers 0120090181
Has Data Monitoring Committee No
U.S. FDA-regulated Product Not Provided
IPD Sharing Statement Not Provided
Responsible Party Lawrence Chin, MD, UMDNJ
Study Sponsor University of Medicine and Dentistry of New Jersey
Collaborators Not Provided
Investigators
Principal Investigator: Lawrence W Chinn, MD UMDNJ-NJMS
PRS Account Rutgers, The State University of New Jersey
Verification Date September 2010