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MiRNAs Evaluate the Prognosis of Sepsis (METPS)

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ClinicalTrials.gov Identifier: NCT01207531
Recruitment Status : Unknown
Verified September 2010 by Chinese PLA General Hospital.
Recruitment status was:  Recruiting
First Posted : September 23, 2010
Last Update Posted : September 23, 2010
Information provided by:
Chinese PLA General Hospital

September 17, 2010
September 23, 2010
September 23, 2010
July 2010
November 2010   (Final data collection date for primary outcome measure)
all cause mortality [ Time Frame: 28days after admited in ICU ]
Same as current
No Changes Posted
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MiRNAs Evaluate the Prognosis of Sepsis
miRNA in the Evaluation of the Value of Sepsis Prognosis Prospective Observational Study
Sepsis is a common cause of death in intensive care unit, timely and accurate diagnosis and treatment directly affect the survival rate. MiRNA is a post-transcriptional small RNA which regulate mRNA expression. The present study was designed to screen several miRNA by microarray which evaluate the sepsis prognosis in order to be a new target for the treatment of sepsis.
The study is a non-intervention, prospective observational study. Purpose of this sudy is to screening several miRNAs by microarray which can evaluate the prognosis of sepsis . We will collect serum samples from patients with sepsis in SICU, RICU and EICU of 301 Hospital since September 2009 , and then use the chip and qRT-PCR to Screen miRNAs which can evaluate the prognosis of sepsis, and statistical analysis the miRNAS expression correlation with SOFA score.
Observational Model: Case Control
Time Perspective: Prospective
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Retention:   Samples Without DNA
human serum
Non-Probability Sample
within 24 hours after admited in ICU
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  • Survival Group
  • Death group
Wang H, Zhang P, Chen W, Feng D, Jia Y, Xie L. Serum microRNA signatures identified by Solexa sequencing predict sepsis patients' mortality: a prospective observational study. PLoS One. 2012;7(6):e38885. doi: 10.1371/journal.pone.0038885. Epub 2012 Jun 15.

*   Includes publications given by the data provider as well as publications identified by ClinicalTrials.gov Identifier (NCT Number) in Medline.
Unknown status
April 2011
November 2010   (Final data collection date for primary outcome measure)

Inclusion Criteria:

  • Clinical diagnosis of sepsis
  • Patients who agree with the study

Exclusion Criteria:

  • Aged <18 years;
  • Into the group who died within 24 hours;
  • Agranulocytosis (<0.5 × 109 / L);
  • Combined HIV infection.
Sexes Eligible for Study: All
18 Years and older   (Adult, Senior)
Contact information is only displayed when the study is recruiting subjects
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Lixin Xie, Pneumology Department of Chinese PLA General Hospital
Chinese PLA General Hospital
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Study Director: Lixin Xie, Doctor Pneumology Department of chinese PLA General Hospital
Chinese PLA General Hospital
September 2010