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Scoring System for Inhalation Injury

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ClinicalTrials.gov Identifier: NCT01194024
Recruitment Status : Active, not recruiting
First Posted : September 2, 2010
Last Update Posted : January 9, 2019
Sponsor:
Collaborator:
U.S. Army Medical Research and Materiel Command
Information provided by (Responsible Party):
American Burn Association

September 1, 2010
September 2, 2010
January 9, 2019
November 2011
September 2019   (Final data collection date for primary outcome measure)
Development of a diagnostic model to predict the severity of inhalation injury [ Time Frame: within 48 hours of admission ]
The development of a diagnostic model to predict the severity of inhalation injury based on demographics, characteristics of injury, bronchoscopy, CT scan, and inflammatory markers.
Not Provided
Complete list of historical versions of study NCT01194024 on ClinicalTrials.gov Archive Site
Impact of inhalation injury [ Time Frame: at discharge ]
Assessment of the impact of inhalation injury on the incidence of pneumonia, acute respiratory distress syndrome (ARDS), and acute lung injury (ALI).
Not Provided
Not Provided
Not Provided
 
Scoring System for Inhalation Injury
Burn Multicenter Proposal: Development of an Inhalation Injury Scoring System to Predict Severity of Inhalation Injury
The goal of this multicenter study is to develop a standardized scoring system for inhalation injury that can be used both to quantify and predict injury severity inhalation injury in adults over 18 years of age. A model will be developed based on clinical, radiographic, bronchoscopic, and biochemical parameters that will predict the severity of inhalation injury with greater than 80% predictive accuracy
Not Provided
Observational
Observational Model: Cohort
Time Perspective: Prospective
Not Provided
Retention:   Samples With DNA
Description:
bronchioalveolar lavage specimens, blood samples
Non-Probability Sample

Study population includes all patients admitted to a participating burn center and who are intubated withing 24 hours of injury

Inhalation Injury
Other: Standard of Care
bronchoscopy with collection of bronchioalveolar lavage specimen, blood samples, High-Resolution spiral computed tomography(CT)
Intubated within 24hrs of admission
All patients that are admitted to a participating burn center and intubated within 24 hours
Intervention: Other: Standard of Care
Not Provided

*   Includes publications given by the data provider as well as publications identified by ClinicalTrials.gov Identifier (NCT Number) in Medline.
 
Active, not recruiting
108
100
September 2019
September 2019   (Final data collection date for primary outcome measure)

Inclusion Criteria:

  • Injury consistent with inhalation of smoke or products of combustion
  • Requires intubation within 24 hours of injury
  • Meets one of the following 4 criteria

    1. history of closed space injury
    2. carbonaceous sputum
    3. elevated carboxyhemoglobin
    4. dx of inhalation injury is considered likely by investigator

Exclusion Criteria:

  • ≤ 17 years of age
  • Prisoner
Sexes Eligible for Study: All
18 Years and older   (Adult, Older Adult)
No
Contact information is only displayed when the study is recruiting subjects
United States
 
 
NCT01194024
ABA-MCTG-0004
No
Not Provided
Not Provided
American Burn Association
American Burn Association
U.S. Army Medical Research and Materiel Command
Principal Investigator: Kevin N. Foster, MD The Arizona burn Center, Maricopa Integrated Health Systems
American Burn Association
June 2018