Post Stroke Psychological Distress (POSTPSYDIS)

This study is currently recruiting participants. (see Contacts and Locations)
Verified February 2015 by Charite University, Berlin, Germany
German Federal Ministry of Education and Research
Information provided by (Responsible Party):
Matthias Endres, Charite University, Berlin, Germany Identifier:
First received: July 1, 2010
Last updated: February 9, 2015
Last verified: February 2015

July 1, 2010
February 9, 2015
October 2009
May 2015   (final data collection date for primary outcome measure)
occurence of depression (GDS, SKID) [ Time Frame: 90 days ] [ Designated as safety issue: No ]
Depression (GDS, SKID) [ Time Frame: 90 days ] [ Designated as safety issue: No ]
Complete list of historical versions of study NCT01187342 on Archive Site
  • change in salivia cortisol [ Time Frame: 90days ] [ Designated as safety issue: No ]
  • change in serumcholine [ Time Frame: 90days ] [ Designated as safety issue: No ]
  • Morphological patterns [ Time Frame: 90days ] [ Designated as safety issue: No ]
  • laboratory test results [ Time Frame: 90days ] [ Designated as safety issue: No ]
  • cognitive and stress related parameters [ Time Frame: 90days ] [ Designated as safety issue: No ]
Not Provided
Not Provided
Post Stroke Psychological Distress
Depression and Posttraumatic Stress Disorder in Stroke Patients: an Observational Study of Neuro-psychiatric, Cognitive, and MR-Changes Over Time After Stroke
Neuro-psychological, cognitive and biochemical assessment matched with MR-Imaging in acute and chronic poststroke conditions.
The study design relates to affective symptomatology, particularly poststroke depression and posttraumatic stress symptoms as well as to cognitive decline due to stress-related hypercortisolemia in the early phase after stroke. Extended MRI studies including a functional connectivity (fc-MRI) paradigm have been incorporated to study on subacute midbrain neurodegeneration as a possible morphological correlate of functional and clinical findings.
Observational Model: Case Control
Time Perspective: Prospective
Not Provided
Retention:   Samples With DNA
Non-Probability Sample
Adult patients with acute ischemic stroke in MCA/AchA territory within 48 hours of onset
Not Provided
  • Non-striatal lesion group
    acute ischemic Stroke in MCA territory of 10-100 cm³ with sparing of striatocapsular structures
  • Striatal lesion group
    acute ischemic stroke in MCA/AchA territory with involvement of at least 125 mm³ of striatocapsular structures
Not Provided

*   Includes publications given by the data provider as well as publications identified by Identifier (NCT Number) in Medline.
December 2015
May 2015   (final data collection date for primary outcome measure)

Inclusion Criteria:

  • Stroke in MCA/AchA territory of striato-capsular (at least 125mm³) or non-striatal (10-100cm³) involvement
  • MR-imaging can be conducted 24-48 hours of onset
  • preserved communication skills

Exclusion Criteria:

  • Patients with psychiatric conditions or medication in the last 4 weeks
  • severe medical conditions
  • limited prognosis
18 Years to 85 Years
Contact: Benjamin G Winter, MD Dr. med. 0049-30-8445 4102
Contact: Golo Kronenberg, MD Prof. Dr. 0049-30-450 560 317
POSTPSYDIS, 4-026-08
Matthias Endres, Charite University, Berlin, Germany
Charite University, Berlin, Germany
German Federal Ministry of Education and Research
Study Director: Matthias Endres, MD, Prof. Dr. med. Center for Stroke Research Berlin
Charite University, Berlin, Germany
February 2015

ICMJE     Data element required by the International Committee of Medical Journal Editors and the World Health Organization ICTRP