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Lung Perfusion With Oxygenated Blood During Aortic Clamping (PulPer-001-Sch)

This study has been completed.
Sponsor:
ClinicalTrials.gov Identifier:
NCT01186510
First Posted: August 23, 2010
Last Update Posted: June 4, 2013
The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details.
Information provided by (Responsible Party):
Arndt-H. Kiessling, Johann Wolfgang Goethe University Hospitals
August 19, 2010
August 23, 2010
June 4, 2013
August 2010
November 2012   (Final data collection date for primary outcome measure)
Inflammatory marker [ Time Frame: 5 days ]
Inflammatory marker
Complete list of historical versions of study NCT01186510 on ClinicalTrials.gov Archive Site
Not Provided
Not Provided
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Lung Perfusion With Oxygenated Blood During Aortic Clamping
Lung Perfusion With Oxygenated Blood During Aortic Clamping

Pulmonary dysfunction presumably linked to an inflammatory response is frequent after cardiac operations using cardiopulmonary bypass (CPB) and pulmonary hypoperfusion.

Aim of the study: To evaluate the protective effect of continuous pulmonary perfusion with oxygenated blood during aortic crossclamping on the inflammatory response.

Not Provided
Interventional
Not Provided
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: None (Open Label)
Primary Purpose: Treatment
Postoperative Pulmonary Dysfunction
  • Procedure: lung perfusion
    see literature of proceeding
  • Procedure: no lung perfusion
    see literature of proceeding
  • Experimental: Lung perfusion
    Intervention: Procedure: lung perfusion
  • Active Comparator: no lung perfusion
    Intervention: Procedure: no lung perfusion
Kiessling AH, Guo FW, Gökdemir Y, Thudt M, Reyher C, Scherer M, Beiras-Fernandez A, Moritz A. The influence of selective pulmonary perfusion on the inflammatory response and clinical outcome of patients with chronic obstructive pulmonary disease undergoing cardiopulmonary bypass. Interact Cardiovasc Thorac Surg. 2014 Jun;18(6):732-9. doi: 10.1093/icvts/ivu062. Epub 2014 Mar 14.

*   Includes publications given by the data provider as well as publications identified by ClinicalTrials.gov Identifier (NCT Number) in Medline.
 
Completed
50
November 2012
November 2012   (Final data collection date for primary outcome measure)

Inclusion Criteria:

  • Age 18-80 ys
  • Cardiopulmonary bypass procedure
  • FEV1 <80%
  • COPD >II

Exclusion Criteria:

  • Emergency cases
Sexes Eligible for Study: All
18 Years to 80 Years   (Adult, Senior)
No
Contact information is only displayed when the study is recruiting subjects
Germany
 
 
NCT01186510
PulPer-001-Sch
No
Not Provided
Not Provided
Arndt-H. Kiessling, Johann Wolfgang Goethe University Hospitals
Johann Wolfgang Goethe University Hospital
Not Provided
Not Provided
Johann Wolfgang Goethe University Hospital
June 2013

ICMJE     Data element required by the International Committee of Medical Journal Editors and the World Health Organization ICTRP