We are updating the design of this site. Learn more.
Show more
ClinicalTrials.gov
ClinicalTrials.gov Menu

Mitochondrial Dysfunction and Oxidative Stress in Chronic Obstructive Pulmonary Disease (COPD) Patients

This study has been completed.
Sponsor:
ClinicalTrials.gov Identifier:
NCT01183052
First Posted: August 17, 2010
Last Update Posted: September 5, 2012
The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details.
Collaborators:
Centre Hospitalier Régional Universitaire Montpellier
Institut National de la Santé Et de la Recherche Médicale, France
Information provided by (Responsible Party):
5 Santé
August 16, 2010
August 17, 2010
September 5, 2012
June 2009
December 2010   (Final data collection date for primary outcome measure)
Cellular effects of exercise training at the ventilatory threshold intensity [ Time Frame: 6 to 8 weeks ]
Same as current
Complete list of historical versions of study NCT01183052 on ClinicalTrials.gov Archive Site
Not Provided
Not Provided
Not Provided
Not Provided
 
Mitochondrial Dysfunction and Oxidative Stress in Chronic Obstructive Pulmonary Disease (COPD) Patients
Mitochondrial Respiratory Chain and Peripheral Muscle Dysfunction in COPD Patients
The purpose of this study is to understand the underlying mechanisms of improved exercise tolerance in COPD patients after training program.
Training protocol used is based on recommendations (Nici et al., 2006) and was previously used in our group (Varray et al., 1991; Vallet et al., 1997). A minimum of 20 sessions in 4-6 weeks were proposed. The exercise intensity of exercise corresponds to target heart rate at ventilatory threshold measured during incremental exercise test. Training at this intensity allowed us to individualize effort for each patient.
Interventional
Not Provided
Intervention Model: Single Group Assignment
Masking: None (Open Label)
COPD Patients
Other: Training
20 sessions of training
Other Name: CT
Training
20 sessions of training
Intervention: Other: Training
Not Provided

*   Includes publications given by the data provider as well as publications identified by ClinicalTrials.gov Identifier (NCT Number) in Medline.
 
Completed
30
December 2010
December 2010   (Final data collection date for primary outcome measure)

Inclusion Criteria:

  • Sedentary mild to severe COPD patients

Exclusion Criteria:

  • Neuromuscular disease
  • Chronic heart failure
  • Renal diseases
  • Liver diseases
  • Obesity
Sexes Eligible for Study: All
50 Years to 75 Years   (Adult, Senior)
No
Contact information is only displayed when the study is recruiting subjects
France
 
 
NCT01183052
2009-A00426-51
Yes
Not Provided
Not Provided
5 Santé
5 Santé
  • Centre Hospitalier Régional Universitaire Montpellier
  • Institut National de la Santé Et de la Recherche Médicale, France
Principal Investigator: Maurice MH Hayot, MCU-PH Institut National de la Santé Et de la Recherche Médicale, France
5 Santé
September 2012

ICMJE     Data element required by the International Committee of Medical Journal Editors and the World Health Organization ICTRP