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Exercise Endothelial Progenitor Cells (EPCs) and Type 2 Diabetes (EPC-DM)

This study is currently recruiting participants.
Verified May 2017 by Steven J. Prior, Ph.D., Baltimore VA Medical Center
Sponsor:
ClinicalTrials.gov Identifier:
NCT01176578
First Posted: August 6, 2010
Last Update Posted: May 2, 2017
The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Know the risks and potential benefits of clinical studies and talk to your health care provider before participating. Read our disclaimer for details.
Collaborator:
University of Maryland
Information provided by (Responsible Party):
Steven J. Prior, Ph.D., Baltimore VA Medical Center
August 5, 2010
August 6, 2010
May 2, 2017
July 2011
September 2018   (Final data collection date for primary outcome measure)
  • Endothelial progenitor cell number [ Time Frame: Baseline ]
  • Endothelial progenitor cell number [ Time Frame: 6-month ]
  • Skeletal muscle capillarization [ Time Frame: Baseline ]
  • Skeletal muscle capillarization [ Time Frame: 6-month ]
Same as current
Complete list of historical versions of study NCT01176578 on ClinicalTrials.gov Archive Site
  • Cardiorespiratory Fitness [ Time Frame: Baseline ]
  • Cardiorespiratory Fitness [ Time Frame: 6-month ]
Same as current
Not Provided
Not Provided
 
Exercise Endothelial Progenitor Cells (EPCs) and Type 2 Diabetes
Exercise Training, CACs, and Vascular Function in Older Veterans With IGT (Impaired Glucose Tolerance)
The discovery of the role of endothelial progenitor cells (EPCs) and their involvement in the cardiovascular complications of type 2 diabetes (T2DM) would quickly have a significant impact on the millions of Americans who have T2DM. This project is designed to 1) determine the mechanisms underlying EPC dysfunction in older, sedentary adults with T2DM compared those with normal glucose metabolism and impaired glucose metabolism, and 2) determine if aerobic exercise training is an efficacious therapy for EPC dysfunction in T2DM, and whether improvement in EPC number and function translates to improved endothelial function, increased capillarization, and improved glucose metabolism in T2DM.
Not Provided
Interventional
Not Provided
Allocation: Non-Randomized
Intervention Model: Parallel Assignment
Masking: None (Open Label)
Primary Purpose: Prevention
Type 2 Diabetes Mellitus
Other: Aerobic Exercise Training
6 months of aerobic exercise training, 3 days per week
  • Experimental: T2DM
    Type 2 Diabetes Mellitus
    Intervention: Other: Aerobic Exercise Training
  • Experimental: IGT
    Impaired Glucose Tolerance
    Intervention: Other: Aerobic Exercise Training
  • Active Comparator: NGT
    Normal Glucose Tolerance
    Intervention: Other: Aerobic Exercise Training
Not Provided

*   Includes publications given by the data provider as well as publications identified by ClinicalTrials.gov Identifier (NCT Number) in Medline.
 
Recruiting
70
Not Provided
September 2018   (Final data collection date for primary outcome measure)

Inclusion Criteria:

  • Age 50-80
  • Non-smoker
  • If woman, postmenopausal >1 year

Exclusion Criteria:

  • History of heart disease or stroke
  • Cancer
  • Poorly controlled hypertension or dyslipidemia
  • Kidney or Liver diseases
Sexes Eligible for Study: All
50 Years to 80 Years   (Adult, Senior)
Yes
Contact: Kim Dormer, MS 410-605-7000 ext 4130 kimberly.dormer@va.gov
United States
 
 
NCT01176578
HP-00047188
Yes
Not Provided
Not Provided
Steven J. Prior, Ph.D., Baltimore VA Medical Center
Baltimore VA Medical Center
University of Maryland
Not Provided
Baltimore VA Medical Center
May 2017

ICMJE     Data element required by the International Committee of Medical Journal Editors and the World Health Organization ICTRP