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Regulation of Endothelial Progenitor Cells by Short-Term Exercise (EPC-Ex)

This study is ongoing, but not recruiting participants.
Sponsor:
ClinicalTrials.gov Identifier:
NCT01169831
First Posted: July 26, 2010
Last Update Posted: February 28, 2017
The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details.
Collaborator:
Baltimore VA Medical Center
Information provided by (Responsible Party):
Steven J. Prior, Ph.D., University of Maryland
July 23, 2010
July 26, 2010
February 28, 2017
July 2011
November 2014   (Final data collection date for primary outcome measure)
  • Baseline Endothelial progenitor cell number [ Time Frame: Day 1 ]
  • Final Endothelial Progenitor Cell Number [ Time Frame: Day 15 ]
Endothelial progenitor cell number [ Time Frame: Baseline, Post-Exercise ]
Complete list of historical versions of study NCT01169831 on ClinicalTrials.gov Archive Site
  • Baseline Endothelial Reactivity [ Time Frame: Day 1 ]
  • Final Endothelial Reactivity [ Time Frame: Day 15 ]
Endothelial Reactivity [ Time Frame: Baseline, Post-exercise ]
Not Provided
Not Provided
 
Regulation of Endothelial Progenitor Cells by Short-Term Exercise
Regulation of Endothelial Progenitor Cells by Short-Term Exercise
Endothelial Progenitor Cells (EPCs) are circulating cells released from bone marrow which are important for maintaining cardiovascular health. The prevalence of cardiovascular disease in older adults is associated with reduced circulating EPC numbers. Studies have shown reduced EPC number and function in old vs. young individuals, and endurance exercise training increases EPC number and function in young adults. Oxidative stress adversely affects endothelial cells and preliminary evidence indicates that oxidative stress negatively affects EPC function. Conversely, regular exercise reduces markers of oxidative stress and may enhance EPC function in older adults. The investigators hypothesize that older endurance-trained athletes and matched sedentary individuals will have markedly divergent EPC function and that altering the physical activity levels of both groups will move them to intermediate points between these two extremes. The investigators also propose that the investigators can "mimic" the effect of exercise training on EPC function in cell culture by altering intracellular levels of a key enzyme and a signaling molecule which the investigators have shown to regulate EPC function with respect to exercise training in young individuals.
Not Provided
Interventional
Not Provided
Allocation: Non-Randomized
Intervention Model: Single Group Assignment
Masking: None (Open Label)
Primary Purpose: Other
  • Aging
  • Exercise
  • Cardiovascular Disease
  • Other: Exercise Training
    2 weeks of daily aerobic exercise training
  • Other: Exercise Cessation
    Stopping all exercise for 2 weeks
  • Experimental: Sedentary Older Adults
    Intervention: Other: Exercise Training
  • Experimental: Older Endurance Athletes
    Intervention: Other: Exercise Cessation
Not Provided

*   Includes publications given by the data provider as well as publications identified by ClinicalTrials.gov Identifier (NCT Number) in Medline.
 
Active, not recruiting
60
November 2018
November 2014   (Final data collection date for primary outcome measure)

Inclusion Criteria:

  • 50-80 years of age, BMI = 18-35 kg/m2, non-smoking, women must be postmenopausal

Exclusion Criteria:

  • history of cardiovascular/cerebrovascular disease, diabetes, cancer, renal, liver disease, HIV; uncontrolled hyperlipidemia/hypertension
Sexes Eligible for Study: All
50 Years to 80 Years   (Adult, Senior)
Yes
Contact information is only displayed when the study is recruiting subjects
United States
 
 
NCT01169831
HP-00045413
Yes
Not Provided
Not Provided
Steven J. Prior, Ph.D., University of Maryland
University of Maryland
Baltimore VA Medical Center
Principal Investigator: Steven J Prior, Ph.D. University of Maryland
Baltimore VA Medical Center
February 2017

ICMJE     Data element required by the International Committee of Medical Journal Editors and the World Health Organization ICTRP