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Clinical Implication of DAC (Detrusor After-contraction) (DAC)

The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details. Identifier: NCT01154946
Recruitment Status : Completed
First Posted : July 1, 2010
Last Update Posted : July 1, 2010
Information provided by:
Seoul National University Hospital

June 29, 2010
July 1, 2010
July 1, 2010
January 2007
December 2008   (Final data collection date for primary outcome measure)
to confirm whether DAC is a true contraction or not [ Time Frame: up to 2 years (2007.Jan-2008.Dec) ]
no change of Pdet when patients cough could confirm that DAC was a true contraction. Because an artifact occurred when a catheter was pressed against bladder wall or urethra, no change of intravesical pressure and increase of abdominal pressure finally induced a negative deflection of Pdet and this change of Pdet could be regarded as an artifact.
Same as current
No Changes Posted
Past medical history including neurological disorders and pelvic irradiation were also included in the database [ Time Frame: up to 2 years (2007.Jan-2008.Dec) ]
One-way analysis of variance and the chi-square test were performed to determine whether there was a relationship between the presence of DAC and the underlying neurogenic and non-neurogenic conditions
Same as current
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Clinical Implication of DAC (Detrusor After-contraction)
A New Approach to Clinical Implication of Detrusor After-contraction (DAC)

The aims of this study are

  • to confirm whether detrusor after-contraction (DAC) is a true contraction or not with a new approach
  • and to understand clinical implication of DAC
The definition of detrusor after-contraction (DAC) is usually accepted as the increase of detrusor pressure (Pdet), whether it is sudden or not, after cessation of urinary flow. The amount of increase in Pdet is sometimes included in the definition of DAC (14, 15, 20 cmH2O or at least two times the level of the maximal Pdet during the voiding phase). However, it is clear that the lack of a well-established definition may induce much bias in the interpretation of the clinical implication of DAC. The previous studies showed a wide range of prevalence.1-4 DAC seemed to occur more frequently in children and the occurrence rate usually decreased with age in urodynamic studies.
Observational Model: Case Control
Time Perspective: Retrospective
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Non-Probability Sample
2,309 patients more than 18 years old with neurogenic or non-neurogenic voiding dysfunction who performed urodynamic studies
Voiding Dysfunction
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DAC group
patients who show detrusor after-contraction during voiding cystometrography (CMG)
Ruarte AC, Podestá ML, Medel R. Detrusor after-contractions in children with normal urinary tracts. BJU Int. 2002 Aug;90(3):286-93.

*   Includes publications given by the data provider as well as publications identified by Identifier (NCT Number) in Medline.
December 2008
December 2008   (Final data collection date for primary outcome measure)

Inclusion Criteria:

  • Indications and selection of patients for conduction of urodynamic studies (UDS) were followed as the recommendation of ICS (international continence society).

Exclusion Criteria:

  • Patients with indwelling catheters, urinary tract infection and urinary stones were excluded from this study
Sexes Eligible for Study: All
18 Years and older   (Adult, Senior)
Contact information is only displayed when the study is recruiting subjects
Korea, Republic of
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Seoul National University Hospital
Seoul National University Hospital
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Principal Investigator: Seung-June Oh, M.D.,Ph.D. Seoul National University Hospital
Seoul National University Hospital
June 2010