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Effect of Enzyme Therapy on Protein Metabolism in Chronic Pancreatitis

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ClinicalTrials.gov Identifier: NCT01154608
Recruitment Status : Completed
First Posted : July 1, 2010
Last Update Posted : July 1, 2010
Information provided by:

June 30, 2010
July 1, 2010
July 1, 2010
April 2005
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transfer of dietary nitrogen to metabolic pools
Same as current
No Changes Posted
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Effect of Enzyme Therapy on Protein Metabolism in Chronic Pancreatitis
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Pancreatic exocrine insufficiency is known to impair nutrient absorption, especially fat, but few data exist about protein absorption. We aimed to investigate this question and assess the enzyme substitution efficiency using a sensitive method.
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Allocation: Randomized
Intervention Model: Crossover Assignment
Primary Purpose: Basic Science
  • Drug: Creon
  • Other: No enzyme therapy
    Current enzyme therapy of the patient is stopped during 7 days
  • Experimental: pancreatic enzymes
    Intervention: Drug: Creon
  • Placebo Comparator: control
    Intervention: Other: No enzyme therapy
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*   Includes publications given by the data provider as well as publications identified by ClinicalTrials.gov Identifier (NCT Number) in Medline.
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Inclusion Criteria:

  • Chronic pancreatitis
  • Pancreatic insufficiency
  • Enzyme therapy treatment

Exclusion Criteria:

  • Hepatic failure
  • Pregnancy
  • Positive serology to HIV, HCV, AGHbS, gastro-intestinal disease
Sexes Eligible for Study: All
18 Years and older   (Adult, Senior)
Contact information is only displayed when the study is recruiting subjects
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Pr Benamouzig, Assistance Publique - Hôpitaux de Paris
Institut National de la Recherche Agronomique
  • National Research Agency, France
  • Solvay Pharmaceuticals
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Institut National de la Recherche Agronomique
May 2010

ICMJE     Data element required by the International Committee of Medical Journal Editors and the World Health Organization ICTRP