Relative Efficacy of Vitamins D2 and D3 in Adult Humans

The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details. Identifier: NCT01139840
Recruitment Status : Completed
First Posted : June 9, 2010
Last Update Posted : October 31, 2011
Health Future Foundation
BTR Group
Information provided by (Responsible Party):
Creighton University

June 7, 2010
June 9, 2010
October 31, 2011
January 2010
August 2010   (Final data collection date for primary outcome measure)
AUC for increment in serum 25(OH)D [ Time Frame: 12 weeks ]
Same as current
Complete list of historical versions of study NCT01139840 on Archive Site
change in vitamin D content of subcutaneous fat [ Time Frame: 12 weeks ]
Same as current
Not Provided
Not Provided
Relative Efficacy of Vitamins D2 and D3 in Adult Humans
Vitamin D Status: Relative Efficacy of Vitamins D2 and D3
Vitamin D2 in chronic dosing will produce less of an elevation of serum 25(OH)D than will the same dose of vitamin D3.
Not Provided
Not Applicable
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: Single (Outcomes Assessor)
Primary Purpose: Prevention
  • Dietary Supplement: vitamin D2
    Study Supplement
  • Dietary Supplement: vitamin D3
    Study Supplement
  • Active Comparator: vitamin D2
    Intervention: Dietary Supplement: vitamin D2
  • Active Comparator: vitamin D3
    Intervention: Dietary Supplement: vitamin D3
Heaney RP, Recker RR, Grote J, Horst RL, Armas LA. Vitamin D(3) is more potent than vitamin D(2) in humans. J Clin Endocrinol Metab. 2011 Mar;96(3):E447-52. doi: 10.1210/jc.2010-2230. Epub 2010 Dec 22.

*   Includes publications given by the data provider as well as publications identified by Identifier (NCT Number) in Medline.
Same as current
September 2010
August 2010   (Final data collection date for primary outcome measure)

Inclusion Criteria:

  • willingness to withhold supplement use for duration of study
  • willingness to avoid sun exposure for duration of study

Exclusion Criteria:

  • vitamin D supplement use
  • conditions that affect vitamin D metabolism by the body
Sexes Eligible for Study: All
21 Years to 65 Years   (Adult)
Contact information is only displayed when the study is recruiting subjects
United States
Not Provided
Not Provided
Creighton University
Creighton University
  • Health Future Foundation
  • BTR Group
Principal Investigator: Robert P Heaney, MD Creighton University
Creighton University
October 2011

ICMJE     Data element required by the International Committee of Medical Journal Editors and the World Health Organization ICTRP