Trial of a Brain Preservation Diet in Preventing Cognitive Decline in Old Age Hostel Residents

The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details. Identifier: NCT01132261
Recruitment Status : Completed
First Posted : May 28, 2010
Last Update Posted : May 28, 2010
Information provided by:
Chinese University of Hong Kong

May 25, 2010
May 28, 2010
May 28, 2010
February 2006
June 2009   (Final data collection date for primary outcome measure)
cognitive decline [ Time Frame: 33 months ]
Same as current
No Changes Posted
  • Change in MMSE test [ Time Frame: 33 months ]
  • % subjects meeting targets of brain preservation diet [ Time Frame: 33 months ]
    brain preservation diet includes 3 portion of vergetables per day, 2 portion of fruit per day, 5 meal of fish per week, 6 glasses of water per day.
Same as current
Not Provided
Not Provided
Trial of a Brain Preservation Diet in Preventing Cognitive Decline in Old Age Hostel Residents
A Randonized Control Trial of a Brain Preservation Diet in Preventing Congnitive Decline in Odl Age Hostel Residents

Dementia is a major cause of disabilities in older people. If the onset of dementia can be delayed by preventive measures, the burden of the disease to the society can be greatly reduced. It is now recognised that dietary factors are related to the incidence of dementia. High intake of vegetables, fruit and fish are protective while high intake of saturated fat and salt (via its effect on blood pressure) are detrimental to risk of dementia.

The investigators therefore propose to perform a randomized controlled trial of dietetic interventions in old age hostels in Hong Kong. Twelve old age hostels under the Tung Wah Group will be randomly assigned to intervention or control groups. The intervention group will receive dietetic interventions by 2 weekly small group discussion with the residents, modification of menu and publicity. The daily diet to be implemented consists of the following principles: 1. fresh fruit 2 portions, 2. vegetables 4 portions, 3. fish, 4. white meat, 5. sodium intake < 100 mmol/L, 6. six glasses of water. In the control group. The dietician will give two health talks and advice on menu only.

The primary outcome is the incidence of questionable dementia in those who are normal at baseline and the incidence of dementia in those who have questionable dementia at baseline. The categorisation will be performed by trained research assistant after administering a structured questionnaire. Change in mini-mental examination score and SF36 quality of life scores are secondary outcomes. Food records over three days for each subject are recorded every three months, to ensure that the brain preservation diet has been adhered to. Half of the subjects will be randomly assigned to have blood and urine tests at baseline and at one year, in order to examine the health effects of dieting.

Not Provided
Not Applicable
Allocation: Non-Randomized
Intervention Model: Parallel Assignment
Masking: Single (Outcomes Assessor)
Primary Purpose: Prevention
  • Cognitive Decline
  • Dietetic Intake
Other: "brain preservation' diet
dietetic evaluation and advice in small group for health diet
  • Active Comparator: 1
    brain preservation diet
    Intervention: Other: "brain preservation' diet
  • No Intervention: 2
Kwok TC, Lam LC, Sea MM, Goggins W, Woo J. A randomized controlled trial of dietetic interventions to prevent cognitive decline in old age hostel residents. Eur J Clin Nutr. 2012 Oct;66(10):1135-40. doi: 10.1038/ejcn.2012.117. Epub 2012 Sep 5.

*   Includes publications given by the data provider as well as publications identified by Identifier (NCT Number) in Medline.
Same as current
June 2009
June 2009   (Final data collection date for primary outcome measure)

Inclusion Criteria:

  • old age home residents age 75 years or above, CDR<1

Exclusion Criteria:

  • tube fed residents
Sexes Eligible for Study: All
75 Years and older   (Senior)
Contact information is only displayed when the study is recruiting subjects
RCT-dietetic intake
Not Provided
Not Provided
Not Provided
Professsor, Thhe Chinese University of Hong Kong
Chinese University of Hong Kong
Not Provided
Not Provided
Chinese University of Hong Kong
January 2009

ICMJE     Data element required by the International Committee of Medical Journal Editors and the World Health Organization ICTRP