Magnetic Resonance Imaging (MRI) and Decline of Aging Aviator Performance

The recruitment status of this study is unknown because the information has not been verified recently.
Verified June 2011 by Stanford University.
Recruitment status was  Active, not recruiting
Information provided by:
Stanford University Identifier:
First received: May 7, 2010
Last updated: June 9, 2011
Last verified: June 2011

May 7, 2010
June 9, 2011
November 2002
December 2012   (final data collection date for primary outcome measure)
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Complete list of historical versions of study NCT01120860 on Archive Site
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Magnetic Resonance Imaging (MRI) and Decline of Aging Aviator Performance
MRI and Decline of Aging Aviator Performance
The primary purpose of this study is to apply state-of-the-art Magnetic Resonance Imaging (MRI) and Magnetic Resonance Spectroscopic Imaging (MRSI) techniques to measure changes over time in the brain.

We expect that MRI and MRSI techniques will be a useful adjunct in research efforts to understand individual differences in performance of a complex attention-demanding task, such as flying a plane or driving a car. Other predictors of change in performance of a complex task may include simple tests of processing speed and working memory, past training and recent practice of the task, and genetic risk factors for degenerative brain disease. In this project, we will examine whether baseline MR measures are as useful as longitudinal MR measures in predicting amount of change over time in task performance.

This research is part of a long-term effort to achieve earlier identification of individuals at risk of decline and ultimately minimize loss of function.

Observational Model: Cohort
Time Perspective: Prospective
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Non-Probability Sample
active healthy pilots
Device: MRI
MRI - routine imaging sequences, designed for anatomical quantification
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*   Includes publications given by the data provider as well as publications identified by Identifier (NCT Number) in Medline.
Active, not recruiting
December 2012
December 2012   (final data collection date for primary outcome measure)

Inclusion Criteria:

  • Subjects will be included if they have participated in the protocol "Age-Related Longitudinal Changes in Aviator Performance" and agree to participate in this protocol.

Exclusion Criteria:

  • Subjects will be excluded if they currently have a major neurological disease, unstable/untreated medical disease (such as untreated hypertension).
  • In consideration of the magnetic fields in which subjects will be placed for the MR scanning, we will also exclude subjects who are unable to safely and comfortably complete the scanning session. This includes individuals who are wearing any metal prosthesis or who have cardiac pacemakers or any other nonremovable metal objects.
  • Subjects reporting a history of severe claustrophobia or poorly controlled back pain will be excluded because it is unlikely they could comfortably remain still in the MRI scanner for the duration of the scan.
  • In addition, subjects who do not fit in the apparatus will also be excluded.
45 Years and older
Contact information is only displayed when the study is recruiting subjects
United States
SU-06302009-2941, 11097
Joy Taylor, Stanford University School of Medicine
Stanford University
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Principal Investigator: Joy Taylor Stanford University
Stanford University
June 2011

ICMJE     Data element required by the International Committee of Medical Journal Editors and the World Health Organization ICTRP