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Vasopressin Deficiency in Hemorrhagic Shock

This study has been completed.
Sponsor:
ClinicalTrials.gov Identifier:
NCT01107314
First Posted: April 20, 2010
Last Update Posted: March 9, 2012
The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details.
Information provided by (Responsible Party):
The University of Texas Health Science Center at San Antonio
April 19, 2010
April 20, 2010
March 9, 2012
February 2010
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Complete list of historical versions of study NCT01107314 on ClinicalTrials.gov Archive Site
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Vasopressin Deficiency in Hemorrhagic Shock
Vasopressin Deficiency in Hemorrhagic Shock
In this study we hope to delineate the typical vasoactive mediator response of trauma patients to shock. We plan to assess serum levels of vasopressin and also catecholamines, angiotensin, and cortisol during resuscitation of trauma patients to delineate high risk populations for vasopressin deficiency.
This is a prospective observational study. The only research-driven procedure will be the removal of blood samples at designated time points(total blood removed 48 cc per patient). Hemodynamic, fluid infusion and agitation/pain data (RAMSEY Score) will prospectively be collected for research purposes. We will collect data from a convenience sample of patients (when research staff is available) over a one year period.
Observational
Time Perspective: Prospective
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Probability Sample
observational study - trauma patients admitted to University Hospital
Body Response to Trauma
Other: Phlebotomy
Blood draws (total 48 cc blood)
trauma patient
SBP less than 90mmHg
Intervention: Other: Phlebotomy
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*   Includes publications given by the data provider as well as publications identified by ClinicalTrials.gov Identifier (NCT Number) in Medline.
 
Completed
81
April 2011
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Inclusion Criteria:

  • Patient is a male or female patient presumed to be at least 18 years of age;
  • Patient has a reported or actual systolic blood pressure < 90 mmHg within 1 hour of arrival to the Emergency Room;
  • Patient has clinical evidence of acute traumatic injury;

Exclusion Criteria:

  • Patient is asystolic or requires CPR prior to arrival;
  • Patient was transferred from an outside facility
  • Patient known to be pregnant
  • Patient known to be prisoner
Sexes Eligible for Study: All
18 Years and older   (Adult, Senior)
No
Contact information is only displayed when the study is recruiting subjects
United States
 
 
NCT01107314
2009-0528-H
A-13969.2 ( Other Grant/Funding Number: DoD )
No
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The University of Texas Health Science Center at San Antonio
The University of Texas Health Science Center at San Antonio
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Principal Investigator: Stephen M Cohn, MD The University of Texas Health Science Center at San Antonio
The University of Texas Health Science Center at San Antonio
March 2012