Thrombus Aspiration in Myocardial Infarction (TASTE)

The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details. Identifier: NCT01093404
Recruitment Status : Completed
First Posted : March 25, 2010
Last Update Posted : July 11, 2016
Uppsala University
Information provided by (Responsible Party):
Ole Frobert, MD, PhD, Region Örebro County

March 22, 2010
March 25, 2010
July 11, 2016
July 2010
March 2013   (Final data collection date for primary outcome measure)
All-cause death [ Time Frame: 30 days ]
Death from any cause will be registered via national registries during the first 30 days after study inclusion.
Same as current
Complete list of historical versions of study NCT01093404 on Archive Site
  • Time to re-hospitalization with nonfatal reinfarction, heart failure and target vessel revascularization [ Time Frame: 30 days to 10 years ]
  • Time to all-cause death or new myocardial infarction (first occurring) or in hospital treatment for heart failure [ Time Frame: 30 days to 10 years ]
  • Time to acute coronary occlusion, stent thrombosis and restenosis in treated lesions [ Time Frame: 1 year ]
  • Length of hospital stay [ Time Frame: 1 month ]
  • TIMI-flow grade [ Time Frame: 3 hours ]
    TIMI-flow, or Thrombolysis in Myocardial Infarction grading of flow is a semiquantitative method to assess coronary artery flow following balloon angioplasty.
  • All-cause death [ Time Frame: 1 year to 10 years ]
Same as current
Not Provided
Not Provided
Thrombus Aspiration in Myocardial Infarction
Thrombus Aspiration in ST- Elevation Myocardial Infarction in Scandinavia
Treatment of myocardial infarction (blood clot in the arteries of the heart) has improved after introduction of 24/7 balloon angioplasty to open the blocked artery. However, the clot itself is not routinely removed but recent data in smaller trials indicate that this might improve recovery and prognosis. In this multicenter study of 5000 patients referred to Scandinavian hospitals for myocardial infarction the investigators test the hypothesis that patients randomized to treatment with thrombus aspiration (removing the blood clot by manual suction) before conventional angioplasty will have a reduced risk of death, fewer rehospitalisations, fewer new myocardial infarctions, reduced risk of heart failure, better coronary artery flow after angioplasty and greater reduction of infarct size compared to patients randomized to conventional angioplasty alone.
Not Provided
Not Applicable
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: Single (Outcomes Assessor)
Primary Purpose: Treatment
Acute Myocardial Infarction
Procedure: Thrombus aspiration
Aspiration of thrombus material before angioplasty
  • Experimental: Thrombus aspiration
    Thrombus aspiration is then followed by standard balloon angioplasty (PCI).
    Intervention: Procedure: Thrombus aspiration
  • Active Comparator: Standard balloon angioplasty (PCI)
    Intervention: Procedure: Thrombus aspiration

*   Includes publications given by the data provider as well as publications identified by Identifier (NCT Number) in Medline.
August 2013
March 2013   (Final data collection date for primary outcome measure)

Inclusion Criteria:

  • Patients with a diagnosis of ST-segment elevation myocardial infarction
  • Correspondence between ECG findings and culprit artery pathoanatomy
  • A minimum of 50% stenosis in culprit artery by visual estimate
  • Possibility to perform thrombus aspiration

Exclusion Criteria:

  • Need for emergency coronary artery bypass grafting
  • Inability to provide informed consent
  • Age below 18 years
  • Previous randomization in the TASTE trial
Sexes Eligible for Study: All
18 Years and older   (Adult, Older Adult)
Contact information is only displayed when the study is recruiting subjects
Denmark,   Iceland,   Sweden
Not Provided
Not Provided
Ole Frobert, MD, PhD, Region Örebro County
Region Örebro County
Uppsala University
Principal Investigator: Ole Fröbert, MD, PhD Region Örebro County
Region Örebro County
July 2016

ICMJE     Data element required by the International Committee of Medical Journal Editors and the World Health Organization ICTRP