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Regulation of Intraarticular and Synovium-related Biomarkers of Osteoarthritis. Effect of Acute Mechanical Joint Loading

This study has been completed.
Sponsor:
ClinicalTrials.gov Identifier:
NCT01090375
First Posted: March 19, 2010
Last Update Posted: March 19, 2010
The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details.
Collaborators:
The Danish Rheumatism Association
Danish Ministry of Health, Internal Affairs
Danish National Research Council
The Danish Medical Research Council
Information provided by:
Bispebjerg Hospital
March 18, 2010
March 19, 2010
March 19, 2010
August 2008
March 2009   (Final data collection date for primary outcome measure)
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No Changes Posted
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Regulation of Intraarticular and Synovium-related Biomarkers of Osteoarthritis. Effect of Acute Mechanical Joint Loading
Not Provided
In the present study the microdialysis method is used to investigate biochemical changes within and around the joint simultaneously in both the resting state and in a joint that had been subjected to exercise. The aim of the present study was, by applying the microdialysis technique, to monitor markers of cartilage breakdown and inflammation in 2 different positions of the knee (inside and in the inner part of the knee capsule) in a group of human females with knee osteoarthritis over a period of 3 hours.
Not Provided
Interventional
Early Phase 1
Intervention Model: Parallel Assignment
Primary Purpose: Basic Science
  • Osteoarthritis
  • Exercise
  • Other: Exercise
  • Other: Non Exercise
  • Experimental: Exercise
    Intervention: Other: Exercise
  • Placebo Comparator: Non Exercise
    Intervention: Other: Non Exercise
Helmark IC, Mikkelsen UR, Børglum J, Rothe A, Petersen MC, Andersen O, Langberg H, Kjaer M. Exercise increases interleukin-10 levels both intraarticularly and peri-synovially in patients with knee osteoarthritis: a randomized controlled trial. Arthritis Res Ther. 2010;12(4):R126. doi: 10.1186/ar3064. Epub 2010 Jul 1.

*   Includes publications given by the data provider as well as publications identified by ClinicalTrials.gov Identifier (NCT Number) in Medline.
 
Completed
Not Provided
Not Provided
March 2009   (Final data collection date for primary outcome measure)

Inclusion Criteria:

  • verified osteoarthritis (x-ray)of the knee, female,

Exclusion Criteria:

  • dementia, inflammatory diseases, regular pain medication
Sexes Eligible for Study: Female
55 Years to 75 Years   (Adult, Senior)
Not Provided
Contact information is only displayed when the study is recruiting subjects
Not Provided
 
 
NCT01090375
H-KF-306126
No
Not Provided
Not Provided
Not Provided
Bispebjerg Hospital
  • The Danish Rheumatism Association
  • Danish Ministry of Health, Internal Affairs
  • Danish National Research Council
  • The Danish Medical Research Council
Not Provided
Bispebjerg Hospital
March 2010

ICMJE     Data element required by the International Committee of Medical Journal Editors and the World Health Organization ICTRP