Impact of Spices and Herbs on Endothelial Function

The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details. Identifier: NCT01085019
Recruitment Status : Completed
First Posted : March 11, 2010
Last Update Posted : June 28, 2012
McCormick Canada Co
Information provided by (Responsible Party):
Charles Couillard, Laval University

March 9, 2010
March 11, 2010
June 28, 2012
March 2010
June 2011   (Final data collection date for primary outcome measure)
Endothelial function measured by endopat system (the endothelium-mediated changes in vacular tone) [ Time Frame: at week 0 and week 4 ]
Same as current
Complete list of historical versions of study NCT01085019 on Archive Site
  • Circulating level of plasma lipoproteins-lipids [ Time Frame: at week 0 and week 4 ]
  • Oxidative stress [ Time Frame: at week 0 and week 4 ]
  • Endothelial activation and inflammatory markers [ Time Frame: at week 0 and week 4 ]
Same as current
Not Provided
Not Provided
Impact of Spices and Herbs on Endothelial Function
Investigation of the Impact of Spices and Herbs on Endothelial Function and Other CVD Risk Factors in Men and Women.
The general objective of the study is to investigate the effects of the daily consumption of spices and herbs for four (4) consecutive weeks in endothelial function and cardiovascular risk factors of men and postmenopausal women.
The purpose is to assess whether the polyphenol/antioxidant content of different spices will affect endothelial function and other cardiovascular risk factors.
Not Applicable
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: Double (Participant, Care Provider)
Primary Purpose: Prevention
Endothelial Function
  • Dietary Supplement: Cinnamon
    2.8g/day of cinnamon in capsules during 4 weeks.
  • Dietary Supplement: Oregano
    2.8g/day of oregano in capsules during 4 weeks.
  • Dietary Supplement: Ginger
    2.8g/day of ginger in capsules during 4 weeks.
  • Dietary Supplement: Rosemary
    2.8g/day of rosemary in capsules during 4 weeks.
  • Dietary Supplement: Black pepper
    2.8g/day of black pepper in capsules for 4 weeks.
  • Dietary Supplement: Placebo
    2.8 g/day of placebo in capsules (corn starch) during 4 weeks.
  • Experimental: Dietary supplement: Cinnamon
    Intervention: Dietary Supplement: Cinnamon
  • Experimental: Dietary supplement: Oregano
    Intervention: Dietary Supplement: Oregano
  • Experimental: Dietary supplement: Ginger
    Intervention: Dietary Supplement: Ginger
  • Experimental: Dietary supplement: Rosemary
    Intervention: Dietary Supplement: Rosemary
  • Experimental: Dietary supplement: Black pepper
    Intervention: Dietary Supplement: Black pepper
  • Placebo Comparator: Dietary supplement: Placebo
    Intervention: Dietary Supplement: Placebo
Carnovale V, Paradis ME, Gigleux I, Ramprasath VR, Couture P, Jones PJ, Lamarche B, Couillard C. Correlates of reactive hyperemic index in men and postmenopausal women. Vasc Med. 2013 Dec;18(6):340-6. doi: 10.1177/1358863X13507975.

*   Includes publications given by the data provider as well as publications identified by Identifier (NCT Number) in Medline.
December 2011
June 2011   (Final data collection date for primary outcome measure)

Inclusion Criteria:

  • Age 40-70 yrs
  • Men and postmenopausal women
  • Waist girth >102cm (men) or >88cm (women)
  • LDL-C > 2.8 mmol/L
  • Framingham 10‐yr risk score < 10%
  • Marginal endothelial dysfunction
  • Non smoker

Exclusion Criteria:

  • Medication for lipid, hypertension, diabetes
  • History of CVD, diabetes, other endocrines disorders
  • Pre‐menopausal women
  • Alcohol consumption > 1 drink per day
  • Unusual dietary habits (e.g. vegetarism)
  • Chronic use of supplements (estrogens, vitamins, minerals or flavonoids)
  • Aversion or intolerance for spices and/or herbs
  • Injury to fingers or amrs that would interfere with endothelial function measurement
Sexes Eligible for Study: All
40 Years to 70 Years   (Adult, Senior)
Contact information is only displayed when the study is recruiting subjects
Not Provided
Not Provided
Charles Couillard, Laval University
Laval University
McCormick Canada Co
Principal Investigator: Charles Couillard, Ph.D Laval University
Laval University
June 2012

ICMJE     Data element required by the International Committee of Medical Journal Editors and the World Health Organization ICTRP