Genetics of Obesity in Chinese Youngs (GOCY)

This study is currently recruiting participants. (see Contacts and Locations)
Verified April 2016 by Shanghai Jiao Tong University School of Medicine
Sponsor:
Information provided by (Responsible Party):
Guang Ning, Shanghai Jiao Tong University School of Medicine
ClinicalTrials.gov Identifier:
NCT01084967
First received: March 10, 2010
Last updated: April 25, 2016
Last verified: April 2016

March 10, 2010
April 25, 2016
March 2009
April 2021   (final data collection date for primary outcome measure)
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Complete list of historical versions of study NCT01084967 on ClinicalTrials.gov Archive Site
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Genetics of Obesity in Chinese Youngs
Study of Clinical Characteristics and Genetic Susceptibility in Chinese Obese Youngs
The purpose of this study is to explore the pathogenesis and genetic susceptibility of obese subjects,providing a convincing argument for further treatment of obesity and metabolic syndrome.

Obesity has become a major worldwide challenge to public health, owing to an interaction between the obesogenic environment and a strong genetic contribution.Previous studies found that genetic factors determine 40%-70% of obese phenotype.Under such circumstances, the screening of obesity susceptibility gene is particularly important for society or family to take measures to prevent obesity.

Recent extensive genome-wide association studies(GWASs) have identified numerous single nucleotide polymorphisms associated with obesity,but these loci together account for only a small fraction of the known heritable component.Two studies in 2010 Nature,for the first time, put rare copy number variation (CNV)in association with severe early-onset obesity.Their significance lie not only in the discovery of the pathogenic genes of severe early-onset obesity but,more importantly,in providing new strategies for finding out genes that cause complex diseases.

Obese patients and healthy lean controls proved by a series of blood biochemical examinations will be enrolled in this study.The present study intends to use the techniques such as enzyme-linked immunosorbent assay, real-time fluorescence quantitative PCR,gene chip,construction of viral vectors,transfection,taking advantage of the established database,by means of serum assays and functional tests, associate copy number variation with obesity phenotype to explain the root cause of obesity.Meanwhile biomarkers and genetic risk factors will be evaluated in the study subjects.

Observational
Observational Model: Cohort
Time Perspective: Cross-Sectional
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Retention:   Samples With DNA
Description:
Whole blood,fasting serum and morning urine
Probability Sample
The population from which cohorts will be selected include students, residents, staff, and/or faculty who are present on Shanghai Jiaotong University school of medicine, and surrounding areas.
  • Obesity
  • Metabolic Syndrome
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  • Healthy lean control group
    BMI:18.5-22.9kg/m2. Age:14-30 years old. To be proved normal by the examinations of liver and kidney function,blood lipids profile,fasting and postprandial plasma glucose, fasting insulin and HbA1c.
  • obesity group with BMI ≥30
    obesity group 1500, lean healthy control group 1500
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*   Includes publications given by the data provider as well as publications identified by ClinicalTrials.gov Identifier (NCT Number) in Medline.
 
Recruiting
3000
April 2021
April 2021   (final data collection date for primary outcome measure)

Inclusion Criteria:

  • body mass index (BMI)≥ 30kg/m2
  • predominantly east China to minimize population stratification
  • willing and able to provide informed consent

Exclusion Criteria:

  • pregnancy/lactation
  • Cushing syndrome
  • Hypothyroidism
  • obesity caused by pituitary and hypothalamic lesions
  • drug related obesity
  • history of major psychiatric illness
Both
14 Years to 30 Years   (Child, Adult)
Yes
Contact: Guang Ning, MD.PhD 86-21-64370045 ext 665340 guangning@medmail.com.cn
Contact: Jie Hong, PhD 86-21-64370045 ext 665345 hongjie13d@hotmail.com
China
 
NCT01084967
CCEMD008
No
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Guang Ning, Shanghai Jiao Tong University School of Medicine
Shanghai Jiao Tong University School of Medicine
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Principal Investigator: Guang Ning, MD.PhD Shanghai Jiao Tong University School of Medicine
Shanghai Jiao Tong University School of Medicine
April 2016

ICMJE     Data element required by the International Committee of Medical Journal Editors and the World Health Organization ICTRP