Transcranial Magnetic Stimulation for Borderline Personality Disorder (SiMaT-B)

The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details. Identifier: NCT01076933
Recruitment Status : Completed
First Posted : February 26, 2010
Last Update Posted : May 11, 2017
Information provided by (Responsible Party):
University Hospital, Toulouse

January 6, 2010
February 26, 2010
May 11, 2017
January 2010
March 2011   (Final data collection date for primary outcome measure)
Tower of London [ Time Frame: Inclusion, 15th day, 30th day and 3rd month ]
Same as current
Complete list of historical versions of study NCT01076933 on Archive Site
  • Balloon Analog Risk Task [ Time Frame: Inclusion, 15th day, 30th day and 3rd month ]
  • Micro-World Test [ Time Frame: Inclusion, 15th day and 3rd month ]
  • Borderline Personality Disorder Severity Index [ Time Frame: Pre-inclusion, 30th day and 3rd month ]
  • Symptom Check List - 90 [ Time Frame: Inclusion, 15th day, 30th day and 3rd month ]
  • Barratt Impulsivity Scale [ Time Frame: Inclusion and 3rd month ]
  • Global Assessment Scale [ Time Frame: Inclusion and 3rd month ]
Same as current
Not Provided
Not Provided
Transcranial Magnetic Stimulation for Borderline Personality Disorder
Effect of Repetitive Transcranial Magnetic Stimulation (rTMS) on Borderline Personality Disorder (BPD)

Primary purpose : to assess the effect on neuropsychological tasks related to planning of 10 daily sessions of right dorsolateral prefrontal cortex with High-frequency repetitive transcranial magnetic stimulation (rTMS) on borderline personality disorder (BPD) patients.

Hypothesis : BPD patients receiving 10 sessions of rTMS will have greater improvement in the average number of move to achieve tasks of the Tower of London, than those receiving sham rTMS.

Not Provided
Not Applicable
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: Triple (Participant, Care Provider, Investigator)
Primary Purpose: Treatment
Borderline Personality Disorder
  • Procedure: repetitive Transcranial Stimulation Magnetic (rTMS)
    The motor threshold was determined in each subject once, before treatment. This was defined as the lowest stimulation intensity capable of inducing a visible movement at least five times out of 10 stimulations. The position of the right dorsolateral prefrontal cortex was defined as 5 cm anterior (in a parasagittal line) to the motor cortex. The stimulus intensity was 80% of the patient's motor threshold intensity. Treatments were given for 20 minutes per day over 10 working days.
  • Procedure: sham rTMS
    sham rTMS
  • Experimental: rTMS
    rTMS sessions
    Intervention: Procedure: repetitive Transcranial Stimulation Magnetic (rTMS)
  • Sham Comparator: control
    sham rTMS (control)
    Intervention: Procedure: sham rTMS
Cailhol L, Roussignol B, Klein R, Bousquet B, Simonetta-Moreau M, Schmitt L, Thalamas C, Tap G, Birmes P. Borderline personality disorder and rTMS: a pilot trial. Psychiatry Res. 2014 Apr 30;216(1):155-7. doi: 10.1016/j.psychres.2014.01.030. Epub 2014 Jan 30.

*   Includes publications given by the data provider as well as publications identified by Identifier (NCT Number) in Medline.
April 2012
March 2011   (Final data collection date for primary outcome measure)

Inclusion Criteria:

  • 20 to 45 years old
  • Borderline Personality Disorder (Diagnostic Interview for Borderline Personality Disorder > 8)
  • psychiatric follow-up
  • righthander
  • informed consent
  • affiliated to medical insurance

Exclusion Criteria:

  • bipolar disorder
  • substance use disorder
  • Major Depressive Disorder or Stress Post Traumatic Disorder
  • history of epilepsy
  • neurosurgery
  • cardiac pacemaker
  • lefthander
  • involuntary admission
  • participation in an other research
  • legal guardianship
  • poor mastery of french.
Sexes Eligible for Study: All
20 Years to 45 Years   (Adult)
Contact information is only displayed when the study is recruiting subjects
08 153 02
AOL 2008
Not Provided
Not Provided
University Hospital, Toulouse
University Hospital, Toulouse
Not Provided
Principal Investigator: Lionel Cailhol, MD University Hospital Toulouse - 31059 Toulouse - France
University Hospital, Toulouse
May 2017

ICMJE     Data element required by the International Committee of Medical Journal Editors and the World Health Organization ICTRP